Moringa oleifera induced potentiation of serotonin release by 5-HT(3) receptors in experimental ulcer model

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Siddhartha DebnathDebjani Guha

Abstract

moringa oleifera (Moringaceae), a perennial plant is widely cultivated throughout the world. Extensive pharmacological studies revealed its promising role in modulation of various disorders like antispasmodic, diuretic, abortifacient, antimicrobial antibacterial, antitubercular, antiviral, antifertility, depressant, anti-inflammatory and anticancer property which promoted us to conduct the study to elucidate its role on experimental gastric ulceration. the aim of the present study was to assess the efficacy of its aqueous leaf extract on protection of gastric ulceration and characterize the possible modulatory mechanism underlying the phenomenon. adult Holtzman strain albino rats (weight 150-200 g) of either sex were used for the study. Ulceration was induced using aspirin (500 mg/kg body weight) and using Moringa oleifera (MO), a herbal formulation, the modulatory mechanism has been studied and compared with a commonly used antagonist of 5-HT(3) receptors, ondansetron by assessing parameters like mean ulcer index, 5-HT content, EC cell count and mucosal thickness. the results of our study suggest that MO protects ulcer formation by modulating 5-HT secretion through EC cell via 5-HT(3) receptors in gastrointestinal tract. MO sh...Continue Reading

References

Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·D E HernandezA J Prange
Jan 1, 1988·Journal of Ethnopharmacology·S ShuklaA O Prakash
Feb 1, 1985·Journal of Pharmacological Methods·S SzaboJ C Bradford
May 1, 1968·Acta Physiologica Scandinavica·A Penttilä
Apr 13, 1995·Biochimica Et Biophysica Acta·U GassenschmidtH Niebergall
Nov 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·D HoyerC Bruns
Apr 21, 1999·Mutation Research·A P GuevaraH Nishino
Jul 10, 1999·Cell and Tissue Research·P Vanden BergheJ Janssens
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
Feb 17, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P Tahiliani, A Kar
Jun 3, 2006·The Journal of Physiology·David Grundy
Aug 3, 2007·European Journal of Pharmacology·Dirk RüschDouglas E Raines
Apr 1, 2008·Human & Experimental Toxicology·R HazraD Guha
Dec 11, 2008·The Journal of Pharmacology and Experimental Therapeutics·Prasun GuhaSandip K Bandyopadhyay
Jul 20, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Siddhartha DebnathDebjani Guha
Jan 1, 2008·Indian Journal of Pharmacology·Babita Agrawal, Anita Mehta

❮ Previous
Next ❯

Citations

Jan 8, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Tanit PadumanondaSuppachai Tiyaworanant
Oct 4, 2016·Pharmacognosy Research·Evangeline E FernandesAlpana S Moghe
Jul 20, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Siddhartha DebnathDebjani Guha
Jul 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mehdi Sharifi-RadJavad Sharifi-Rad
Mar 27, 2015·Phytotherapy Research : PTR·Sidney J Stohs, Michael J Hartman
Mar 20, 2013·Journal of Basic and Clinical Physiology and Pharmacology·Ademola A OyagbemiHelen O Nottidge
Mar 6, 2018·Frontiers in Pharmacology·Nur Zahirah Abd RaniEndang Kumolosasi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.