Moringa oleifera Lam. (Moringaceae) grown in Nigeria: In vitro antisickling activity on deoxygenated erythrocyte cells.

Journal of Pharmacy & Bioallied Sciences
Olufunmilayo E AdejumoAkintomiwa O Folarin

Abstract

Traditional medicine, which is more available and affordable for the poor uses medicinal plants for the treatment and management of various ailments, including the sickle cell disease (SCD). About 24 million Nigerians are carriers of this sickled cell gene, while approximately 2.4 million are SCD patients. Moringa oleifera Lam. (Moringaceae) possesses high nutritional value and has been used in folklore medicine to treat various ailments related to pain and inflammation. Chemical, pharmacological and pharmacognostical applications of Moringa oleifera have been reported. This study investigated the antisickling potential of polar and non-polar extracts of the seed, flower and leaf of Moringa oleifera for the first time. Using crude methanol extract, aqueous extract, ethyl acetate and butanol, the in vitro antisickling activities of Moringa oleifera fractions, were evaluated using erythrocyte cells deoxygenated with 2% sodium metabisulphite. p-Hydroxybenzoic acid and normal saline were employed as positive and negative controls. Phytochemical screening revealed the presence of saponins, free anthraquinones, and alkaloids. Extracts of the seed and flower demonstrated a higher (P<0.05) antisickling activity in comparison to the lea...Continue Reading

References

Nov 8, 2006·Phytotherapy Research : PTR·Farooq AnwarAnwarul Hassan Gilani
Jun 13, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arti R VermaChandana V Rao

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Citations

Dec 19, 2013·PloS One·Larissa Cardoso Corrêa AraújoPatrícia Maria Guedes Paiva
Oct 10, 2012·Pharmaceutical Biology·Syazana Akmal SharifudinPalanisamy Arulselvan
Apr 29, 2015·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·André TibiriInnocent Pierre Guissou
Jan 1, 2014·International Scholarly Research Notices·Santosh Kumar Maurya, Anil Kumar Singh
Mar 7, 2021·International Journal of Molecular Sciences·Coralia CotoraciAnca Hermenean

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