Moringa oleifera leaf and seed inclusive diets influenced the restoration of biochemicals associated with erectile dysfunction in the penile tissue of STZ-induced diabetic male rats treated with/without Acarbose drug.
Abstract
We aim to evaluate the effect of Moringa leaf (ML) and seed (MS) inclusive diets on critical biomarkers [acetylcholinesterase (AChE), monoamine oxidase (MAO), angiotensin-I converting enzyme (ACE), adenosine deiminase (ADA) and arginase activities, and thiobarbituric acid reactive species (TBARS) level] associated with erectile dysfunction (ED) in the penile tissue of diabetic male rats treated with/without Acarbose (ACA). About 60 mg/kg BW streptozotocin (STZ)-induced diabetic rats were fed with ML and MS inclusive diets and cotreated with ACA for 14 days. The result indicated that AChE, MAO, ADA, ACE, and arginase activities, as well as TBARS level were (p < .05) restored in the diabetic rats fed with ML/MS inclusive diets treated with/without ACA compared to the untreated diabetic rats. In conclusion, the combination therapy of ML/MS inclusive diets plus ACA could be explored toward the management of diabetic-induced ED. PRACTICAL APPLICATIONS: We discovered in this study, treatments of diabetic rats with ACA and co-fed with 2% and 4% of Moringa leaf and seed inclusive diets for 14 days, could be of great benefit toward the management of ED caused by diabetes, as evidenced by the expression of some ED-related biomarkers in t...Continue Reading
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