Morning hyperglycemic excursions: a constant failure in the metabolic control of non-insulin-using patients with type 2 diabetes

Diabetes Care
L MonnierH Boniface

Abstract

To determine whether, over daytime, one or several hyperglycemic excursions exist that can be general failures in the glycemic control of patients with type 2 diabetes. In 200 non-insulin-using patients with type 2 diabetes, diurnal plasma glucose and insulin profiles were studied. Plasma glucose concentrations were measured after an overnight fast (at 8:00 A.M. immediately before breakfast), during the postprandial period (at 11:00 A.M. and 2:00 P.M.), and during the postabsorptive period (at 5:00 P.M., extended postlunch time). In the population considered as a whole, prelunch glucose concentrations (12.0 mmol/l) were found to be significantly increased (P < 0.0001) when compared with those observed at 8:00 A.M. (8.8 mmol/l), at 2:00 P.M. (10.5 mmol/l), and at 5:00 P.M. (8.6 mmol/l). Similar significant excursions (P < 0.0001) in prelunch glucose were observed within subsets of patients selected from the following criteria: 1) body weight, 2) HbA(1c), 3) categories of treatment, and 4) residual beta-cell function. From the calculation of areas under the daytime glucose curves, the relative contributions of postprandial and fasting glucose to the total glucose increment were found to be similar. High plasma glucose excursions ...Continue Reading

References

Sep 3, 1992·The New England Journal of Medicine·S DinneenR Rizza
Jun 1, 1990·Diabetes Care·M C Riddle
Apr 24, 2001·Diabetes Care·UNKNOWN American Diabetes Association

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Citations

Sep 10, 2008·Current Diabetes Reports·Louis Monnier, Claude Colette
Oct 18, 2005·The American Journal of Medicine·Jaime Davidson
Feb 6, 2004·Diabetes Research and Clinical Practice·Mitsuhiro NakazakiChuwa Tei
Feb 27, 2007·Vascular Health and Risk Management·Catherine A SchnabelOrville Kolterman
May 1, 2010·International Journal of Diabetes in Developing Countries·Shahram Haddadinezhad, Nargess Ghazaleh
Oct 29, 2014·Diabetology & Metabolic Syndrome·Kenjiro ImaiMitsuhiko Noda
Dec 6, 2006·Medicine and Science in Sports and Exercise·Stephan F PraetLuc J van Loon
Oct 22, 2008·Expert Opinion on Pharmacotherapy·Louis Monnier, Claude Colette
Dec 30, 2015·European Journal of Applied Physiology·Jonida HaxhiMassimo Sacchetti
Nov 6, 2007·Diabetes Research and Clinical Practice·Melanie DaviesUNKNOWN AT.LANTUS Study Group
Jun 2, 2007·Diabetes Research and Clinical Practice·Rie OkaSusumu Miyamoto
Feb 27, 2007·Diabetes & Metabolism·L MonnierH Boniface
Mar 3, 2007·Journal of Diabetes and Its Complications·Jan SzewieczekGrzegorz Kawecki
Dec 14, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Glen H MurataJayendra H Shah
Jul 4, 2006·Diabetes Research and Clinical Practice·Marie-Claude BrindisiRémi Rabasa-Lhoret
Apr 19, 2011·Diabetes Research and Clinical Practice·Jan-Willem van DijkLuc J C van Loon
Apr 5, 2016·Postgraduate Medicine·Jessica E MatthewsMolly C Carr
Dec 3, 2014·Diabetes & Metabolism·L MonnierD Owens
Jul 12, 2014·Journal of Diabetes and Its Complications·Bo AhrénRonnie Aronson
Dec 3, 2014·The Medical Clinics of North America·Farah Meah, Rattan Juneja
Nov 13, 2009·Diabetes Care·Louis Monnier, Claude Colette
Apr 30, 2003·Diabetes Care·Mayer B Davidson
Nov 5, 2016·Diabetes Research and Clinical Practice·Makoto OharaTsutomu Hirano
Jun 3, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·D RaccahH Schmitt
May 20, 2017·Journal of Applied Physiology·Melissa L EricksonNathan T Jenkins
Apr 15, 2006·Clinical Science·Stephan F E PraetLuc J C van Loon
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Mary F CarrollDavid S Schade

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