Morning Plasma Melatonin Differences in Autism: Beyond the Impact of Pineal Gland Volume

Frontiers in Psychiatry
Anna MaruaniRichard Delorme

Abstract

While low plasma melatonin, a neuro-hormone synthesized in the pineal gland, has been frequently associated with autism, our understanding of the mechanisms behind it have remained unclear. In this exploratory study, we hypothesized that low melatonin levels in ASD could be linked to a decrease of the pineal gland volume (PGV). PGV estimates with magnetic resonance imaging (MRI) with a voxel-based volumetric measurement method and early morning plasma melatonin levels were evaluated for 215 participants, including 78 individuals with ASD, 90 unaffected relatives, and 47 controls. We first found that both early morning melatonin level and PGV were lower in patients compared to controls. We secondly built a linear model and observed that plasma melatonin was correlated to the group of the participant, but also to the PGV. To further understand the relationship between PGV and melatonin, we generated a normative model of the PGV relationship with melatonin level based on control participant data. We found an effect of PGV on normalized melatonin levels in ASD. Melatonin deficit appeared however more related to the group of the subject. Thus, melatonin variations in ASD could be mainly driven by melatonin pathway dysregulation.

References

May 8, 1998·Journal of Pineal Research·C GrahamD K Smith
Jan 17, 2003·Molecular and Cellular Biology·Xiaowei JinDavid R Weaver
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jan 18, 2005·Biological Psychiatry·Sylvie TordjmanYvan Touitou
Sep 27, 2006·Child Psychiatry and Human Development·Xianchen LiuJames B Adam
Feb 14, 2007·Human Brain Mapping·Amanda Bischoff-GretheBruce Fischl
May 17, 2007·Molecular Psychiatry·J MelkeT Bourgeron
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·T Bourgeron
Sep 16, 2008·The Journal of Genetic Psychology·Muriel C Lopez-WagnerJames E Gilliam
Feb 12, 2009·Brain Structure & Function·Roberto ToroTomás Paus
Jul 25, 2009·Journal of Magnetic Resonance Imaging : JMRI·Ingo NölteChristoph Groden
Aug 12, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Bo SunShuwei Liu
Dec 26, 2009·Clinical Neurology and Neurosurgery·Ingo NolteJohann Scharf
Jan 1, 2010·Sleep·Margaret C SoudersJennifer Pinto-Martin
Apr 27, 2011·Developmental Medicine and Child Neurology·Daniel A Rossignol, Richard E Frye
Jan 1, 2008·Environmental Health Insights·Xue MingGeorge C Wagner
May 28, 2011·Journal of Pineal Research·Pauline ChasteThomas Bourgeron
Jun 28, 2011·Journal of Affective Disorders·Samuel SarrazinJosselin Houenou
Dec 14, 2011·Journal of Autism and Developmental Disorders·Beth MalowCourtney Burnette
Apr 13, 2012·Autism Research : Official Journal of the International Society for Autism Research·Mayada ElsabbaghEric Fombonne
Feb 26, 2013·Autism Research : Official Journal of the International Society for Autism Research·Amy Jo SchwichtenbergSally Ozonoff
Apr 30, 2013·Journal of Autism and Developmental Disorders·Jill A HollwayEric Butter
Oct 17, 2013·International Journal of Molecular Sciences·Sylvie TordjmanJulie Vernay-Leconte
Nov 12, 2013·Journal of Magnetic Resonance Imaging : JMRI·Luisa-Sophie LiebrichIngo S Nölte
Mar 13, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Stefano GabrieleAntonio M Persico
May 13, 2014·Nature Genetics·So-Youn ShinNicole Soranzo
Sep 17, 2014·Molecular Psychiatry·R ToroUNKNOWN IMAGEN consortium
Feb 24, 2015·Brain Disorders & Therapy·Alina MastersSamy I McFarlane
Aug 21, 2015·Nature Reviews. Neuroscience·Thomas Bourgeron
Sep 4, 2015·American Journal of Medical Genetics. Part a·Anna MaruaniRichard Delorme
Mar 2, 2016·Biological Psychiatry·Andre F MarquandChristian F Beckmann
Jul 28, 2016·Journal of Biological Rhythms·Lara G SigurdardottirLorelei A Mucci
Nov 20, 2016·Developmental Medicine and Child Neurology·Paul Gringras

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Citations

Nov 5, 2019·Current Pharmaceutical Design·Luciana PinatoSanseray da Silveira Cruz-Machado
Dec 29, 2020·Journal of Pineal Research·Guillaume DumasThomas Bourgeron
Aug 4, 2019·Behavioural Brain Research·Lucie JurekMarie-Maude Geoffray

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