Morning salivary cortisol versus short Synacthen test as a test of adrenal suppression

Annals of Clinical Biochemistry
Rajan S PatelA Michael Wallace

Abstract

The short Synacthen test (SST) is the most commonly used test for the assessment of adrenal suppression. We investigated the potential of a simpler and more cost-effective procedure [morning salivary cortisol (MSC)] as an outpatient screening tool to detect adrenal suppression in patients using topical intranasal corticosteroids for rhinosinusitis. Forty-eight patients who were using topical corticosteroids underwent adrenal function assessment by way of SST and MSC measurement. Sixteen of the 48 patients had impaired MSCs. Of these 16 patients, 15 had an impaired SST (sensitivity 100%) and one had a normal SST. All patients with normal MSCs also had normal SSTs (specificity 97%). The morning salivary cortisol measurement is a useful screening tool for adrenal suppression in this setting.

Citations

Jan 27, 2009·European Journal of Endocrinology·Miguel DebonoJohn Newell-Price
Jan 29, 2013·Psychiatry Research·Eva KočovskáHelen Minnis
Apr 5, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Joanne BlairRichard Ross
Oct 20, 2006·Acta Oto-laryngologica·Pierre BonfilsDavid Malinvaud
Jan 30, 2009·Annals of Clinical Biochemistry·Peter Wood

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