PMID: 9527644Apr 4, 1998Paper

Morphine-6-glucuronide-induced locomotor stimulation in mice: role of opioid receptors

Pharmacology & Toxicology
Merete GrungJørg Mørland

Abstract

Morphine-6beta-glucuronide is a major metabolite of morphine with potent analgesic actions. To explore the importance of this opiate when administered as a drug by its own or in morphine action, we studied the locomotor activity response to morphine and morphine-6-glucuronide in drug-naive C57 BL/6JBom mice. The effects of administration of the two opiates on a battery of 7 different locomotor activities were studied and compared to saline controls. A dose of 20 micromol/kg morphine-6-glucuronide resulted in more locomotion than the same dose of morphine, while at higher doses (up to 120 micromol/kg), similar increases for most locomotor behaviours were recorded for both drugs. Pretreatment with naltrindole indicated that the delta-receptors play an equivalent but minor role in mediating both morphine-6-glucuronide and morphine hyperlocomotion. Administration of high naltrexone doses (10 mg/kg) completely abolished the locomotor stimulation induced by both opiates. However, at intermediate naltrexone doses of 0.25 and 0.5 mg/kg, morphine-induced behaviours was completely inhibited while morphine-6-glucuronide induced behaviours demonstrated partial resistance to naltrexone inhibition. The mu1-specific receptor antagonist naloxo...Continue Reading

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Citations

Jul 6, 2002·European Journal of Pharmacology·Angelo ContarinoLisa H Gold
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·M GrungJ Mørland
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·Marte HandalJørg Mørland
Jun 17, 2011·The Clinical Journal of Pain·Howard S Smith
Mar 4, 2014·Experimental Brain Research·Antonio Rodríguez-GaztelumendiAlvaro Díaz
Mar 9, 2007·Pharmacology, Biochemistry, and Behavior·Marte HandalJørg Mørland
May 25, 2016·The Journal of Pharmacology and Experimental Therapeutics·Anne Marte Sjursen KvelloInger Lise Bogen
Apr 5, 2014·The Journal of Pharmacology and Experimental Therapeutics·Inger Lise BogenJannike Mørch Andersen
May 23, 2015·Scandinavian Journal of Immunology·E IdzkowskaM Moniuszko
Oct 28, 2019·International Journal of Molecular Sciences·Beatriz Herrero-FernandezJose Maria Gonzalez-Granado
Feb 23, 2019·Addiction Biology·Anne Marte Sjursen KvelloInger Lise Bogen
Jun 23, 2009·The Journal of Pharmacology and Experimental Therapeutics·Jannike Mørch AndersenJørg Mørland

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