PMID: 8582789Sep 1, 1995Paper

Morphine affects cytostatic activity of macrophages by the modulation of nitric oxide release

International Journal of Immunopharmacology
R PacificiD Pietraforte

Abstract

The serum levels of morphine and its glucuronide metabolites were quantitated in C57BL/6 mice at various intervals following subcutaneous administration of morphine. Since one of the major mechanisms of killing by macrophages is the production of nitric oxide, pharmacokinetics data were correlated with cytostatic activity and the release of NO2- (stable end product of NO metabolism). Morphine and its 3-glucuronide metabolite appear in serum of treated mice, reaching a peak of concentration at 20 min. However, morphine 3'-glucuronide levels were much higher than those of the drug itself, even when the morphine concentration levelled off. Both cytostasis and NO2- production of L1210-activated macrophages were significantly enhanced by opioid treatment immediately after drug injection (peaking after 40 min). In contrast, morphine induced a strong inhibition of both cytostasis and NO2- production 24 h after treatment. The modulation of both cytostasis and NO2- production induced by morphine was completely antagonized by pretreatment of mice with the opioid antagonist naltrexone. The involvement of an inducible isoform of NO synthase was suggested by the inhibitory effects of dexamethasone on NO2- production. These data indicate tha...Continue Reading

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Citations

Nov 19, 2009·Journal of Anesthesia·Noboru TodaHiroshi Toda
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Sabita RoyJosephine Martin
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Prati Pal Singh, Priya Singal
Sep 1, 2009·Indian Journal of Microbiology·Raman Preet SinghPrati Pal Singh
Sep 16, 2000·International Journal of Immunopharmacology·R PacificiP Zuccaro
Jul 7, 2009·Critical Care Clinics·Robert D SandersMervyn Maze
Jan 15, 2008·Life Sciences·Raman Preet SinghPrati Pal Singh
May 8, 1998·Biochemical and Biophysical Research Communications·S RoyR A Barke
May 3, 2000·Medical Hypotheses·I D WeltersG B Stefano
Oct 6, 2006·Current Opinion in Anaesthesiology·Ingeborg D Welters
Aug 1, 1997·Natural Product Reports·K W Bentley
Jan 6, 2021·International Journal of Molecular Sciences·Jana BrejchovaPetr Svoboda

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