Morphine and clonidine synergize to ameliorate low back pain in mice.

Pain Research and Treatment
Maral TajerianLaura S Stone

Abstract

Chronic low back pain (LBP) is a debilitating condition associated with signs of axial and radiating pain. In humans with chronic LBP, opioids are often prescribed with varying outcomes and a multitude of side effects. Combination therapies, in which multiple pharmacological agents synergize to ameliorate pain without similar potentiation of adverse reactions, may be useful in improving therapeutic outcome in these patients. The SPARC-null mouse model of low back pain due to disc degeneration was used to assess the effects of opioid (morphine) and α(2)-adrenergic agonist (clonidine) coadministration on measures of axial and radiating pain. The results indicate that systemic morphine and clonidine, coadministered at a fixed dose of 100 : 1 (morphine : clonidine), show a synergistic interaction in reversing signs of axial LBP, in addition to improving the therapeutic window for radiating LBP. Furthermore, these improvements were observed in the absence of synergy in assays of motor function which are indicative of side effects such as sedation and motor incoordination. These data show that the addition of low-dose systemic clonidine improves therapeutic outcome in measures of both axial and radiating pain. Combination therapy cou...Continue Reading

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Citations

Sep 30, 2014·Peptides·Richard J Bodnar
Sep 4, 2015·The Spine Journal : Official Journal of the North American Spine Society·Magali MillecampsLaura S Stone
Mar 31, 2015·European Journal of Pharmacology·Carolyn A Fairbanks, Cory J Goracke-Postle
Mar 20, 2014·British Journal of Pharmacology·A-J Chabot-DoréG L Wilcox
Jul 4, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Magali MillecampsLaura S Stone

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Methods Mentioned

BETA
sedation
Assay
pharmacotherapy
transgenic

Software Mentioned

FlashCalc

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