Morphine bioavailability from a topical gel formulation in volunteers

Journal of Pain and Symptom Management
Judith A PaiceMichael J Avram

Abstract

Although available therapies provide relief to many patients with cancer-related pain, swallowing difficulties or intestinal obstruction may preclude oral analgesic delivery in some. Topical morphine might provide an alternate delivery form but morphine bioavailability from a topical gel formulation has not been reported in humans. We conducted a randomized, placebo-controlled, double-blind, crossover study of five volunteers after they provided institutionally-approved, written, informed consent. They were admitted to the Northwestern University General Clinical Research Center twice, being randomly assigned to receive either 1mL of morphine compounded at 10mg/mL in pluronic lecithin organogel (PLO) base applied to the wrist and 1mL of normal saline administered subcutaneously, or 1mL of topical drug-free PLO base and 1mL of subcutaneous morphine, 3mg/mL, the first time and the opposite combination the second. Seventeen blood samples were collected from 5minutes to 10hours after dose administration for morphine concentration determination. Plasma samples were prepared by solid-phase extraction and morphine concentrations measured by a mass spectrometric technique with a linear range of 0.5-500ng/mL. Bioavailability of the topi...Continue Reading

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Citations

Nov 26, 2015·Drug Development and Industrial Pharmacy·Hashem AlsaabSai Hs Boddu
Jul 6, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Matthew G KestenbaumJ Cameron Muir
Feb 5, 2013·Mayo Clinic Proceedings·Charles E Argoff
Jun 26, 2012·Journal of Pain and Symptom Management·Naoki InuiHiroshi Watanabe
May 9, 2012·Journal of Pain and Symptom Management·Thomas J SmithGwendolyn Parker
May 18, 2010·Biomaterials·Guillaume BastiatJean-Christophe Leroux
May 6, 2011·CA: a Cancer Journal for Clinicians·Judith A Paice, Betty Ferrell
Jul 2, 2020·Drug Design, Development and Therapy·Neha MaharaoJyotika Varshney
Jun 23, 2018·Journal of Burn Care & Research : Official Publication of the American Burn Association·Lu YangElof Eriksson

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