PMID: 8942325Oct 1, 1996Paper

Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination

British Journal of Anaesthesia
J E MontgomeryJ R Sneyd

Abstract

Paracetamol and diclofenac have different mechanisms of action, and the combination may be more effective than each drug used alone in treating postoperative pain. In a double-blind, controlled design, we studied 60 patients undergoing elective abdominal gynaecological surgery, who received suppositories of paracetamol 1.5 g, diclofenac 100 mg or a combination of the two before the start of surgery. Patients received morphine in the intraoperative period, and cumulative morphine use from a patient-controlled analgesia system was recorded to measure the analgesic effect of the suppositories. Morphine consumption was greatest in the group that received paracetamol alone and lowest in the group given the combination (P < 0.01). There was no difference in the incidence of morphine-related side effects between the groups. We conclude that a diclofenac-paracetamol combination reduced the amount of morphine used compared with paracetamol alone.

Citations

Jan 11, 2001·Pharmacology & Therapeutics·R D MacPherson
Nov 7, 2000·Acta Anaesthesiologica Scandinavica·V Dahl, J C Raeder
Jun 5, 1998·Anaesthesia·J E Montgomery, J R Sneyd
May 27, 2003·British Journal of Anaesthesia·A NgA C Davidson
Oct 29, 2003·Paediatric Drugs·Eva Kokinsky, Eva Thornberg
Nov 30, 2006·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·V AkandeD Cahill
Oct 22, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·A TroïtzkyB Debaene
Jul 23, 2009·Pain Practice : the Official Journal of World Institute of Pain·Naresh DhawanNeeti Makhija
Feb 24, 2015·Anesthesiology Clinics·Jeanette R Bauchat, Ashraf S Habib
Mar 7, 2002·British Journal of Anaesthesia·M D SmithR P Symonds
Nov 22, 2002·European Journal of Anaesthesiology·C Lentschener, Y Ozier
May 28, 2005·European Journal of Anaesthesiology·O FourcadeK Samii
Oct 5, 2006·Current Opinion in Anaesthesiology·G P Joshi, P F White
Apr 12, 2002·BMC Clinical Pharmacology·Susanne AmmonGerd Mikus
Aug 23, 2020·Journal of Minimally Invasive Gynecology·Rebecca StoneErica Weston
Sep 29, 1998·Annales Françaises D'anesthèsie Et De Rèanimation·J X Mazoit
Mar 7, 2002·British Journal of Anaesthesia·M E Stocker, J E Montgomery

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