Morphine for chronic neuropathic pain in adults.

The Cochrane Database of Systematic Reviews
Tess E CooperR Andrew Moore

Abstract

Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the nervous system. Opioid drugs, including morphine, are commonly used to treat neuropathic pain. Most reviews have examined all opioids together. This review sought evidence specifically for morphine; other opioids are considered in separate reviews. To assess the analgesic efficacy and adverse events of morphine for chronic neuropathic pain in adults. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase for randomised controlled trials from inception to February 2017. We also searched the reference lists of retrieved studies and reviews, and online clinical trial registries. We included randomised, double-blind trials of two weeks' duration or longer, comparing morphine (any route of administration) with placebo or another active treatment for neuropathic pain, with participant-reported pain assessment. Two revie...Continue Reading

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Citations

Mar 7, 2020·Journal of Oral Science·Masamichi ShinodaKoichi Iwata
Jul 1, 2020·European Endocrinology·Yatan Pal Singh BalharaSanjay Kalra
Feb 10, 2020·Journal of Neural Transmission·Daniela C RosenbergerRolf-Detlef Treede
Aug 11, 2019·Biological Psychiatry·Clifford J Woolf
Oct 30, 2020·Journal of Psychiatry and Brain Science·Boris Tabakoff, Paula L Hoffman
May 8, 2021·Current Pain and Headache Reports·Prashant N RaoMark Jones
Aug 7, 2021·Toxins·Rafael González-CanoFrancisco R Nieto

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