Morphine-induced conditioned taste aversions in the LEW/N and F344/N rat strains

Pharmacology, Biochemistry, and Behavior
D LancellottiA L Riley

Abstract

Previous reports have shown that the LEW/N and F344/N inbred rat strains display a differential sensitivity to cocaine in a number of preparations, with the LEW/N rats displaying an increased sensitivity to both the reinforcing and aversive effects of cocaine (relative to the F344/N rats). Given that the LEW/N rats are also more sensitive to the reinforcing effects of morphine than the F344/N strain, the present experiment examined the ability of morphine to condition taste aversions in the LEW/N and F344/N strains to determine if the general sensitivity to cocaine generalizes to another drug of abuse. Specifically, on four conditioning trials, 35 LEW/N and 33 F344/N female rats were allowed access to a novel saccharin solution and then injected with varying doses of morphine (0, 10, 32 and 56 mg/kg). On intervening recovery days, subjects were allowed 20-min access to water. Following the fourth trial, a final aversion test was administered. The F344/N rats, but not the LEW/N rats, rapidly acquired morphine-induced taste aversions at all doses of morphine. Pharmacokinetic differences between the strains were also assessed. Specifically, 10 mg/kg morphine (or vehicle) was administered to subjects of both strains and plasma morp...Continue Reading

References

Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·T SuzukiR A Meisch
Nov 1, 1992·Neuroendocrinology·J R GlowaE M Sternberg
Jun 28, 1992·Annals of the New York Academy of Sciences·G Di ChiaraE Carboni
Sep 1, 1991·Brain Research Bulletin·T Yamamoto, Y Fujimoto
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·S Pournaghash, A L Riley
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E M SternbergR L Wilder
Feb 1, 1989·Trends in Pharmacological Sciences·F R George, S R Goldberg
Oct 1, 1987·Pharmacology, Biochemistry, and Behavior·A BecharaD van der Kooy
Jan 1, 1985·Annals of the New York Academy of Sciences·K C Chambers
Oct 1, 1974·Journal of Comparative and Physiological Psychology·M Nachman, J H Ashe
Sep 1, 1974·Pharmacology, Biochemistry, and Behavior·L F Parker, B L Radow
Oct 1, 1972·Journal of Comparative and Physiological Psychology·B D Berger
Feb 1, 1984·Pharmacology, Biochemistry, and Behavior·D A ZellnerA L Riley
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·D R Woolfolk, S G Holtzman
Feb 1, 1995·Pharmacology, Biochemistry, and Behavior·S SiegelI Moroz
Mar 1, 1995·Neuroscience Research·T YamamotoN Sakai
Oct 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E J Nestler
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·B A Gosnell, D D Krahn
May 20, 1998·Pharmacology, Biochemistry, and Behavior·T StöhrJ Feldon
May 6, 1999·Brain Research Bulletin·S Reilly
Feb 9, 2000·Psychopharmacology·W J Lynch, M E Carroll
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·A C HutchinsonA L Riley

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Citations

Oct 3, 2006·Psychopharmacology·Peter G RomaAnthony L Riley
Nov 1, 2003·Pharmacology, Biochemistry, and Behavior·Jovita F Randall-Thompson, Anthony L Riley
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Nathan A DeCarolisAnthony L Riley
Jan 22, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Dec 26, 2001·Psychoneuroendocrinology·Therese A Kosten, Emilio Ambrosio
Nov 19, 2013·Pharmacology, Biochemistry, and Behavior·Alison G P Wakeford, Anthony L Riley
Oct 7, 2014·Pharmacology, Biochemistry, and Behavior·Heather E KingAnthony L Riley
Oct 15, 2011·Drug and Alcohol Dependence·Alexa G DeskoAnthony L Riley
Nov 13, 2008·Pharmacology, Biochemistry, and Behavior·Melissa K Stephens, Anthony L Riley
May 26, 2007·Pharmacology, Biochemistry, and Behavior·Catherine M Davis, Anthony L Riley
Feb 20, 2007·Pharmacology, Biochemistry, and Behavior·Catherine M DavisAnthony L Riley
Feb 15, 2007·Developmental Psychobiology·Peter G RomaAnthony L Riley
Jan 6, 2009·Alcoholism, Clinical and Experimental Research·Chuang LiuPatricia Sue Grigson
Mar 6, 2010·Annals of the New York Academy of Sciences·Catherine M Davis, Anthony L Riley
Jun 17, 2006·Pharmacology, Biochemistry, and Behavior·Meredith A FoxAnthony L Riley
Jan 18, 2006·Pharmacology, Biochemistry, and Behavior·Karen A PescatoreAnthony L Riley
Jul 12, 2005·Pharmacology, Biochemistry, and Behavior·Gregory D BusseAnthony L Riley
Oct 7, 2015·Frontiers in Neuroscience·Tamara J Phillips, Shkelzen Shabani
Oct 30, 2013·Developmental Psychobiology·Zachary E HurwitzAnthony L Riley
Dec 15, 2010·Pharmacology, Biochemistry, and Behavior·Jennifer L Cobuzzi, Anthony L Riley
Aug 4, 2011·Pharmacology, Biochemistry, and Behavior·Janani M VishwanathAnthony L Riley
Aug 28, 2012·Neuroscience and Biobehavioral Reviews·Andrey Verendeev, Anthony L Riley
Jan 21, 2012·Pharmacology, Biochemistry, and Behavior·Catherine M DavisAnthony L Riley
Dec 2, 2010·Physiology & Behavior·Anthony L Riley
Oct 27, 2004·Pharmacology, Biochemistry, and Behavior·Melissa M Foynes, Anthony L Riley
Nov 27, 2018·Physiological Reviews·Lindsey A Schier, Alan C Spector
Apr 23, 2008·Current Protocols in Neuroscience·Anthony L Riley, Kevin B Freeman
Jun 28, 2003·Natural Product Reports·Kenneth W Bentley

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