Morphine-induced degradation of the host defense barrier role of intestinal mucosal injury

Digestive Diseases and Sciences
Lia FrenklakhPravin C Singhal

Abstract

The effect of morphine on intestinal ulcer formation and on the degradation of the host defense barrier was studied. Mice receiving morphine (MRM) showed mucosal ulcer formation in the ileum and in the upper third of the colon. In in vitro studies, morphine enhanced apoptosis of cultured human colonic cells (HCC). Nitric oxide synthase (NOS) inhibitors attenuated the proapoptotic effect of morphine. Moreover, morphine stimulated NO generation by HCCs. MRM also showed a breach in the host defense barrier as well as injury to peritoneal macrophages. Although NOS inhibitors completely prevented morphine-induced intestinal ulcer formation, it provided only partial protection against a breach in the host defense barrier and peritoneal macrophage injury. Propranolol did not inhibit the induction of intestinal ulcer formation in MRM; nevertheless, propranolol prevented a breach in the host defense barrier as well as macrophage injury in MRM, whereas hemin exacerbated macrophage injury as well as the breach in the host defense barrier of MRM. These findings suggest that morphine-induced intestinal injury is mediated through NO generation. However, the degradation of the host defense barrier correlates with macrophage injury, but not in...Continue Reading

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Citations

Nov 19, 2009·Journal of Anesthesia·Noboru TodaHiroshi Toda
Jun 26, 2013·British Journal of Anaesthesia·M Al-HashimiD G Lambert
Oct 17, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Travis Yamanaka, Ruxana T Sadikot
Dec 29, 2010·International Journal of Nanomedicine·Saba NaqviAmit K Dinda
Jan 25, 2018·Journal of Gastrointestinal Cancer·Mohammed Azeez AlzaidiFarhang Sasani
Jan 24, 2020·Current Treatment Options in Oncology·Adrian SzczepaniakMarta Zielińska
Oct 18, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Renata ZajączkowskaJerzy Wordliczek

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