PMID: 8947932Nov 1, 1996Paper

Morphine-induced increase in D-1 receptor regulated signal transduction in rat striatal neurons and its facilitation by glucocorticoid receptor activation: possible role in behavioral sensitization

Neurochemical Research
A N SchoffelmeerG H Tjon

Abstract

One month (but not 1-3 days) after intermittent morphine administration, the hyperresponsiveness of rats toward the locomotor effects of morphine and amphetamine was associated with an increase in dopamine (DA) D-1 receptor-stimulated adenylyl cyclase activity and enhanced steady state levels of preprodynorphin gene expression in slices of the caudate/putamen and nucleus accumbens. Such an enduring increase in postsynaptic D-1 receptor efficacy also occurred in cultured gamma-aminobutyric acid (GABA) neurons of the striatum obtained from rats prenatally treated with morphine. Interestingly, in vitro glucocorticoid receptor activation in these cultured striatal neurons by corticosterone potentiated this neuroadaptive effect of prior in vivo morphine exposure. Since activation of glucocorticoid receptors by corticosterone did not affect D-1 receptor functioning in cultured neurons of saline-pretreated rats, prior intermittent exposure to morphine (somehow) appears to induce a long-lasting state of corticosterone hyperresponsiveness in striatal neurons. Therefore, DA-sensitive striatal GABA neurons may represent common neuronal substrates acted upon by morphine and corticosterone. We hypothesize that the delayed occurrence of thes...Continue Reading

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Citations

Jun 1, 2005·Pharmacology & Therapeutics·Val J Watts, Kim A Neve
Dec 26, 2001·Brain Research. Brain Research Reviews·J G Liu, K J Anand
Aug 26, 1998·Drug and Alcohol Dependence·D W Self, E J Nestler
Feb 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bruce T HopeRoy A Wise
Feb 24, 2010·Frontiers in Neuroendocrinology·Valerie L HedgesRobert L Meisel
Sep 5, 2006·Brain Research·J Thomas CurtisZuoxin Wang
Oct 1, 2003·British Journal of Pharmacology·Julie SalzmannFlorence Noble
Oct 6, 1997·Science·E J Nestler, G K Aghajanian
Oct 26, 2006·Pharmacology·Parviz HeidariMohammad-Reza Zarrindast

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