Morphine-induced venodilation in humans

Clinical Pharmacology and Therapeutics
M GrossmannB B Hoffman

Abstract

Morphine has been extensively used in the treatment of pulmonary edema, and its action is believed to be mediated in part by its ability to produce peripheral venodilation. This study investigated whether opiates produce venodilation in human hand veins and explored the underlying mechanism(s). Fifteen healthy volunteers (11 men and four women) were studied with use of the dorsal hand vein compliance technique. After preconstriction with the selective alpha 1-adrenergic receptor agonist phenylephrine, dose-response curves were constructed to (1) opiate receptor agonists morphine (1 to 30 micrograms/min) or fentanyl (0.07 to 1 microgram/min), (2) a combination of morphine and the mu-opiate receptor antagonist naloxone, and (3) morphine and a combination of histamine (H1 and H2) receptor antagonists. Infusion of morphine caused venodilation in a dose-dependent manner, whereas fentanyl did not produce venodilation. Coinfusion of naloxone and morphine impaired the venodilation only slightly. Coinfusion of the H1- and H2-antagonists completely abolished the venodilatory effect of morphine. These results suggest that the venodilatory effect of morphine is mediated through histamine release and that mu-opiate receptors have little or ...Continue Reading

References

Sep 1, 1978·The American Journal of Physiology·K M BaldwinR E Lewis
Mar 1, 1978·Clinical Pharmacology and Therapeutics·K A PopioP N Yu
Dec 16, 1992·JAMA : the Journal of the American Medical Association·E A Jones, N V Bergasa
Jun 1, 1991·Canadian Journal of Physiology and Pharmacology·T Y el-SharkawyC W Pilcher
May 1, 1989·Anesthesiology·J H LevyB F Walker
May 1, 1988·Pain·J C BallantyneD B Carr
Feb 1, 1982·Anesthesiology·C E RosowJ J Savarese
Oct 1, 1983·Anesthesiology·J Moss, C E Rosow
May 1, 1983·Clinical Pharmacology and Therapeutics·N R FahmyN A Soter
Apr 1, 1995·International Archives of Allergy and Immunology·V PatellaG Marone
Jan 1, 1993·Anaesthesia·D E WithingtonF Reynolds
Mar 1, 1994·The Journal of Allergy and Clinical Immunology·W D DachmanB B Hoffman

❮ Previous
Next ❯

Citations

Mar 1, 2014·Substance Abuse Treatment, Prevention, and Policy·Ute MaurerReinhart Jarisch
Oct 3, 2009·PM & R : the Journal of Injury, Function, and Rehabilitation·Diana D Cardenas, Elizabeth R Felix
May 27, 2016·Physiological Reports·Alvaro F Vargas PelaezMatthew D Muller
May 19, 2011·The Annals of Pharmacotherapy·Colin FeeneyTom Frohlich
Feb 6, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·UNKNOWN American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharm
Nov 1, 2008·Emergency Medicine Australasia : EMA·Luke Hermann, Andy Jagoda
Jul 9, 2004·Emergency Medicine Australasia : EMA·Colin A Graham
Oct 3, 1998·Clinical Pharmacology and Therapeutics·M GrossmanW Kirch
Apr 18, 2009·British Journal of Clinical Pharmacology·Reza AfshariD Nicholas Bateman
Jan 16, 2013·Nature Reviews. Cardiology·Andrew L Clark, John G F Cleland
Dec 11, 2014·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Christoffer Ellingsrud, Stefan Agewall
Aug 9, 2003·Expert Opinion on Drug Safety·Lynne G MaxwellShobha Malviya
Jun 2, 2011·Acute Cardiac Care·Zaza IakobishviliUNKNOWN Heart Failure Survey in Isarel (HFSIS) Investigators
Mar 21, 2002·Critical Care Medicine·Judith JacobiUNKNOWN Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), America
Mar 5, 2016·Clinical and Experimental Dermatology·P M YeoS P R Lim
Sep 21, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Adian IzwanShane K Maloney
Aug 11, 2020·Cardiac Failure Review·Oren Caspi, Doron Aronson
Apr 12, 2003·Critical Care Clinics·Daniela LeviYevgeny Savransky
May 1, 1997·Seminars in Veterinary Medicine and Surgery (small Animal)·M G Papich
Aug 10, 2000·The Veterinary Clinics of North America. Small Animal Practice·M G Papich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
M GyöngyösiZ Jambrik
Chemical Immunology and Allergy
María L SanzM Ferrer
The American Journal of Emergency Medicine
A ChumpaM W Shannon
© 2021 Meta ULC. All rights reserved