Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model

Scientific Reports
Fuyuan WangSabita Roy

Abstract

Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression and gastrointestinal disorders limit their long-term use. In the current study, a morphine-murine model was used to investigate the role of the gut microbiome and metabolome as a potential mechanism contributing to the negative consequences associated with opioid use. Results reveal a significant shift in the gut microbiome and metabolome within one day following morphine treatment compared to that observed after placebo. Morphine-induced gut microbial dysbiosis exhibited distinct characteristic signatures, including significant increase in communities associated with pathogenic function, decrease in communities associated with stress tolerance and significant impairment in bile acids and morphine-3-glucuronide/morphine biotransformation in the gut. Moreover, expansion of Enterococcus faecalis was strongly correlated with gut dysbiosis following morphine treatment, and alterations in deoxycholic acid (DCA) and phosphatidylethanolamines (PEs) were associated with opioid-induced metabolomic changes. Collectively, these results indicate that morphine induced distinct alter...Continue Reading

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References

Apr 27, 1988·European Journal of Pharmacology·H U BryantJ W Holaday
Oct 1, 1985·Biochemical Pharmacology·A S KosterJ Noordhoek
Nov 1, 1971·Journal of Medical Microbiology·G HawksworthM J Hill
Jan 1, 1982·European Journal of Clinical Pharmacology·G M PacificiA Rane
Jul 1, 1997·The Journal of Infectious Diseases·M E HilburgerT K Eisenstein
Aug 21, 2001·Clinical Pharmacokinetics·J Lötsch, G Geisslinger
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinghua WangSabita Roy
Jan 26, 2006·The Journal of Biological Chemistry·Yannick GoumonMarie-Hélène Metz-Boutigue
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Jan 18, 2008·The Journal of Infectious Diseases·Ju Young ChangVincent B Young
Feb 19, 2008·Trends in Microbiology·Bärbel Stecher, Wolf-Dietrich Hardt
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·T Andrew ClaytonJeremy K Nicholson
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Sep 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jerry M WellsPeter van Baarlen
Mar 1, 2011·Trends in Endocrinology and Metabolism : TEM·Thomas Greiner, Fredrik Bäckhed
Mar 3, 2011·MBio·Sandrine P ClausJeremy K Nicholson
Sep 22, 2011·The American Journal of the Medical Sciences·Andrea L MoraKevin W Garey
Jan 10, 2012·Annual Review of Immunology·Kenya Honda, Dan R Littman
Jun 8, 2012·Science·Jeffrey I Gordon
Jun 8, 2012·Science·Jeremy K NicholsonSven Pettersson
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Dec 1, 2012·Current Opinion in Gastroenterology·Vittoria BuccigrossiAlfredo Guarino
Dec 18, 2012·Immunology·Trevor D Lawley, Alan W Walker
Feb 26, 2013·Nature Reviews. Microbiology·Felix Sommer, Fredrik Bäckhed
Nov 29, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alexa R WeingardenAlexander Khoruts
Mar 4, 2014·Current Opinion in Microbiology·Tu Anh N Pham, Trevor D Lawley
Mar 19, 2014·Gastroenterology·Luke K UrsellRob Knight
May 2, 2015·Drug Design, Development and Therapy·Wojciech Leppert
Nov 30, 2016·Toxicologic Pathology·Fuyuan Wang, Sabita Roy
Apr 9, 2017·The Journal of Biological Chemistry·Samuel J Pellock, Matthew R Redinbo

❮ Previous
Next ❯

Citations

Sep 5, 2018·The European Journal of Neuroscience·Rebecca S HoffordDrew D Kiraly
Feb 27, 2019·Psychopharmacology·Sofia CussottoJohn F Cryan
Sep 28, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin LeeAnna M W Taylor
Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Nov 1, 2018·Nature Medicine·Wudan Yan
Jan 10, 2020·Paediatric Drugs·Jean C DinhBridgette L Jones
Mar 30, 2019·Current Opinion in Anaesthesiology·Elvedin LukovicDaniel E Freedberg
Feb 23, 2020·Metabolites·Elke HumerChristoph Pieh
Nov 25, 2019·The International Journal of Neuropsychopharmacology·Shan LiChun Yang
Jan 3, 2020·Behavioural Pharmacology·Michelle Ren, Shahrdad Lotfipour
Apr 22, 2020·Nature·Romana R Gerner, Manuela Raffatellu
Dec 20, 2018·Frontiers in Aging Neuroscience·Serena VerdiClaire J Steves
Jan 24, 2020·Current Treatment Options in Oncology·Adrian SzczepaniakMarta Zielińska
Jun 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Li ZhangSabita Roy
Apr 15, 2019·Psychopharmacology·Katherine R Meckel, Drew D Kiraly
Sep 23, 2020·Molecular Pharmacology·Kyle E ParkerReam Al-Hasani
Jun 4, 2019·International Journal of Food Sciences and Nutrition·Hajara AslamFelice N Jacka
May 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Susanna FürstMahmoud Al-Khrasani
Oct 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Raiza R BonomoVirginie Mansuy-Aubert
Nov 4, 2020·Experimental Neurobiology·Tae-Yong ChoiJa Wook Koo
Dec 29, 2020·Journal of Neurochemistry·Rubén García-CabrerizoJohn F Cryan
Feb 19, 2021·Pharmacological Reviews·Mariana Angoa-Pérez, Donald M Kuhn
Nov 29, 2020·Immunology Letters·Matteo SantoniNicola Battelli
Jun 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lola Rueda-RuzafaPablo Roman
Jun 24, 2020·Peptides·Richard J Bodnar
Apr 1, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Samuel D JohnsonSiddappa N Byrareddy
Apr 9, 2021·Peptides·Richard J Bodnar
Jun 7, 2019·Trends in Pharmacological Sciences·Reese Hitchings, Libusha Kelly
Apr 25, 2021·Neuroscience and Biobehavioral Reviews·Shoshana EitanJacob Kuempel
Jun 16, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebecca S HoffordDrew D Kiraly
Jul 16, 2021·Nature Reviews. Endocrinology·Robyn M BrownPriya Sumithran

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Datasets Mentioned

BETA
E-MTAB-5546
E-MTAB-5550

Methods Mentioned

BETA
Illumina sequencing
MDS
PCR

Software Mentioned

MassLynx TM
QuanLynx TM
Microbiome R
GraphPad Prism
QIIME
ArrayExpress
PCoA
Microbiome R package

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