Morphine mouthwash for the management of oral mucositis in patients with head and neck cancer

Advanced Biomedical Research
Mostafa SarvizadehArmindokht Shahsanai

Abstract

Oral mucositis is a debilitating side effect of cancer treatment for which there is not much successful treatments at yet. We evaluated the effectiveness of topical morphine compared with a routine mouthwash in managing cancer treatment-induced mucositis. Thirty head and neck cancer patients with severe mucositis (World Health Organization Grade III or IV) were randomized into the morphine and magic mouthwash groups. Patients received morphine sulfate 2% or magic solution (contained magnesium aluminum hydroxide, viscous lidocaine, and diphenhydramine), 10 ml for every 3 h, six times a day, for 6 days. Both groups received same dietary and oral hygiene instructions and care. Mucositis was graded at baseline and every 3 days after treatment. Patients' satisfaction and drug effect maintenance were also evaluated. Twenty-eight patients (mean age of 49.5 ± 13.2 years, 63.3% female) completed the trial; 15 in the morphine group and 13 in the magic group. There was a decrease in mucositis severity in both of the morphine (P < 0.001) and magic (P = 0.049) groups. However, at the 6(th) day, more reduction was observed in mucositis severity in the morphine compared with magic group (P = 0.045). Drug effect maintenance was similar between...Continue Reading

References

Apr 15, 2011·The Cochrane Database of Systematic Reviews·Helen V WorthingtonTasneem Khalid

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Citations

Apr 17, 2019·JAMA : the Journal of the American Medical Association·Sharon Elad, Noam Yarom
Oct 17, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carryn M AndersonJohn M Buatti
Nov 13, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Paolo BossiRoberta Depenni
Jun 6, 2020·Pharmaceutics·Jake G EdmansHelen E Colley
Apr 13, 2017·BioMed Research International·Heinz-Dieter MüllerReinhard Gruber
Jun 8, 2017·Frontiers in Oncology·Osama Muhammad MariaThierry Muanza
Feb 14, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Deborah P SaundersUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Apr 3, 2019·International Journal of Molecular Sciences·Agnieszka StempniewiczZygmunt Warzecha
Feb 13, 2020·JCO Oncology Practice·Timothy J Brown, Arjun Gupta
Apr 26, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Loren Madden KirkPaul O Lewis
May 11, 2021·Integrative Cancer Therapies·Angela R Zambrano, Francisco J Bonilla-Escobar
Aug 1, 2020·Reviews on Recent Clinical Trials·Areti GkantaifiMaria Tolia

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Clinical Trials Mentioned

NCT01837446

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