Morphine, pethidine and buprenorphine disposition in the cat

Journal of Veterinary Pharmacology and Therapeutics
Polly M TaylorM Bloomfield

Abstract

Pharmacokinetics of morphine, buprenorphine and pethidine were determined in 10 cats. Six cats received morphine (0.2 mg/kg) intravenously and four intramuscularly. Five received buprenorphine (0.01 mg/kg) intravenously and six intramuscularly. Six received pethidine (5 mg/kg) intramuscularly. Jugular venous blood samples were collected at time points to 24 h, and plasma morphine concentrations were measured by high performance liquid chromatograpy (HPLC), buprenorphine by radioimmunoassay (RIA) and pethidine by gas chromatography. Our data for morphine show elimination half-life (t1/2el) 76.3 min intravenous (i.v.) and 93.6 min intramuscular (i.m.); mean residence time (MRT) 105.0 and 120.5 min; clearance (Clp) 24.1 and 13.9 mL/kg/min; and volume of distribution (V(dss)) 2.6 and 1.7 L/kg, respectively. Comparable data for buprenorphine are t1/2el 416.8 and 380.2 min; MRT 417.6 and 409.8 min; Clp 16.7 and 23.7 mL/kg/min; and V(dss) 7.1 and 8.9 L/kg. For i.m. pethidine, t1/2el 216.4 min; MRT 307.5 min; Clp 20.8 mL/kg/min and V(dss) 5.2 L/kg. For i.m. dosing, the tmax for morphine, buprenorphine and pethidine were 15, 3 and 10 min, respectively. The pharmacokinetics of the three opioids in cats are broadly comparable with those o...Continue Reading

References

Aug 1, 1979·Journal of Pharmaceutical Sciences·L Z Benet, R L Galeazzi
Jul 1, 1978·Clinical Pharmacology and Therapeutics·D R StanskiE Lowenstein
Nov 1, 1978·British Journal of Anaesthesia·J R RiggC H Goldsmith
Jan 1, 1975·Clinical Pharmacology and Therapeutics·L E MatherC Wilkerson
Dec 1, 1975·British Journal of Anaesthesia·L E MatherA E Pflug
Jan 1, 1992·Cancer Chemotherapy and Pharmacology·J R BaldwinP K Narang
Jun 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·J E IlkiwD McNeal
Mar 24, 1990·Lancet·P A GlareC E Pippenger
May 1, 1990·Biopharmaceutics & Drug Disposition·E R Garrett, V R Chandran
Mar 1, 1989·Journal of Analytical Toxicology·C W HandH J McQuay
Dec 1, 1987·British Journal of Clinical Pharmacology·A P FisherM Hanna
Jun 1, 1968·British Journal of Pharmacology and Chemotherapy·B M CoxO H Osman
Dec 1, 1984·British Journal of Clinical Pharmacology·D R GuayG R Grahame
May 1, 1982·British Journal of Clinical Pharmacology·R E BullinghamR A Moore
Nov 1, 1980·Clinical Pharmacology and Therapeutics·R E BullinghamM R Bennett
Dec 1, 1994·Journal of Veterinary Pharmacology and Therapeutics·S DohooA Donald
Aug 1, 1993·Anesthesia and Analgesia·E P SteffeyA R Elliott
Aug 1, 1993·Clinical Pharmacology and Therapeutics·R OsborneM Slevin
Jan 14, 1999·Journal of Veterinary Pharmacology and Therapeutics·B RanheimN E Søli
Jan 1, 1994·The Physician and Sportsmedicine
Jan 1, 2000·Veterinary Anaesthesia and Analgesia·M J DixonP M Taylor
Apr 1, 2001·Veterinary Anaesthesia and Analgesia·S A RobertsonC Waters

❮ Previous
Next ❯

Citations

Sep 15, 2004·Journal of Feline Medicine and Surgery·S A Robertson, P M Taylor
Sep 15, 2004·Journal of Feline Medicine and Surgery·P M Taylor, S A Robertson
Sep 4, 2007·Journal of Feline Medicine and Surgery·Paulo V M SteagallMichael J Dixon
Aug 5, 2008·Journal of Feline Medicine and Surgery·Sheilah A RobertsonBenedict Duncan X Lascelles
Feb 24, 2009·Journal of Feline Medicine and Surgery·Juliana Tabarelli BrondaniCarlos Roberto Padovani
Oct 20, 2009·Journal of Feline Medicine and Surgery·Polly M TaylorKaren E Church
Jan 4, 2007·American Journal of Veterinary Research·Samantha R UhrigPeter W Hellyer
Jun 4, 2008·American Journal of Veterinary Research·Ursula KrotscheckAmy A Little
Jul 18, 2002·Journal of the American Veterinary Medical Association·Sheilah Ann Robertson
Oct 7, 2005·Journal of Veterinary Pharmacology and Therapeutics·S A RobertsonJ W Sear
Oct 27, 2004·Journal of Veterinary Pharmacology and Therapeutics·K WegnerW W Muir
May 3, 2007·Journal of Veterinary Pharmacology and Therapeutics·C Ingvast-LarssonK Olsson
Nov 7, 2006·Veterinary Anaesthesia and Analgesia·Lilia A Goyenechea JaramilloLudo J Hellebrekers
May 11, 2007·Veterinary Anaesthesia and Analgesia·Paulo V M SteagallTatiana H Ferreira
Nov 7, 2006·Journal of Veterinary Pharmacology and Therapeutics·P V M SteagallT H Ferreira
Feb 24, 2007·Veterinary Anaesthesia and Analgesia·Kirsten Wegner, Sheilah A Robertson
Mar 6, 2012·Research in Veterinary Science·M W HarmonA E DeCLue
Sep 26, 2015·Journal of Feline Medicine and Surgery·Louisa S SlingsbyJoanna C Murrell
Sep 21, 2016·Journal of Veterinary Pharmacology and Therapeutics·R J JohnsonJ R E Del Castillo
May 27, 2017·Journal of Feline Medicine and Surgery·Rebecca J BhallaEnzo Vettorato
Jan 4, 2005·The Veterinary Clinics of North America. Small Animal Practice·Sheilah A Robertson
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Dec 7, 2013·Journal of Feline Medicine and Surgery·Thierry BethsKirby Pasloske
Apr 3, 2015·Journal of Feline Medicine and Surgery·Elisa Bortolami, Emma J Love
Sep 13, 2017·Journal of Feline Medicine and Surgery·Thaleia-Rengina StathopoulouLudovic Pelligand
Jul 11, 2018·Journal of Feline Medicine and Surgery·Sheilah A RobertsonGregg M Griffenhagen
Jul 22, 2008·Journal of Veterinary Pharmacology and Therapeutics·A G P GuedesM A Rider
Sep 24, 2010·Journal of Veterinary Pharmacology and Therapeutics·P M SinghP Chambers
Jun 27, 2019·Journal of Veterinary Emergency and Critical Care·Michael R NystromChika C Okafor
Feb 18, 2011·Journal of Veterinary Pharmacology and Therapeutics·K T SiaoJ E Ilkiw
Mar 12, 2011·Journal of Veterinary Pharmacology and Therapeutics·J L DavisL P Posner
Jul 31, 2013·Journal of Veterinary Pharmacology and Therapeutics·C D van BeusekomJ A Schrickx
Mar 25, 2014·Journal of Veterinary Internal Medicine·P V M SteagallP M Taylor
May 28, 2014·Journal of Veterinary Pharmacology and Therapeutics·A R HedgesJ E Ilkiw
Jun 14, 2003·The Veterinary Record·S A RobertsonJ W Sear
Aug 17, 2010·Research in Veterinary Science·Tanya Duke-NovakovskiPaulo V M Steagall
Apr 25, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Nathalie C NewbyE Don Stevens
Apr 20, 2011·Veterinary Anaesthesia and Analgesia·Kristen M MessengerLysa P Posner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.