PMID: 6540199Aug 1, 1984Paper

Morphine responsiveness and seizure proneness

Experimental Neurology
A Mansour, E S Valenstein

Abstract

Previous research demonstrated that following amygdala kindling, animals showed a heightened sensitivity to morphine's convulsive effects and an exaggerated Straub tail response. These effects were evident to 3 months after their last convulsion and could be blocked by naloxone pretreatment. The present paper extends these findings by demonstrating that animals given metrazol or electroshock (ECS) convulsions also showed an enhanced morphine response that was blocked by naltrexone. Both metrazol- and ECS-treated animals convulsed in response to doses of morphine that produced little or no effect in control animals. In addition, it was shown that brain damage induced by electrode implantation or neocortex penetration by skull screws also increased an animal's sensitivity to morphine even in the absence of prior convulsions. This effect, however, could not be blocked by naltrexone. Finally, as opiate receptors vary with the diurnal rhythm, we determined that following amygdala kindling, animals are more sensitive to morphine's convulsive action during their dark phase when receptor number and sensitivity are highest. The results indicated that seizure proneness, whether induced by a history of prior convulsions or brain damage, i...Continue Reading

References

Jan 15, 1978·Experimental Neurology·J P Pinel, L I Rovner
Jan 1, 1974·The Journal of Pharmacy and Pharmacology·I H Ayhan
Jan 1, 1981·Neuroscience Letters·D NaberM S Kafka
Nov 1, 1982·Neuropharmacology·O C Snead, L J Bearden
Dec 16, 1982·Brain Research·H FrenkG Urca
Nov 18, 1982·Brain Research·S Caldecott-HazardJ C Liebeskind
Oct 1, 1982·Experimental Neurology·J P Fabisiak, W S Schwark
Dec 1, 1981·Physiology & Behavior·A MansourE S Valenstein
Sep 1, 1980·Pharmacology, Biochemistry, and Behavior·G Urca, H Frenk

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