PMID: 2096088Jan 1, 1990Paper

Morpho-functional state of the spermatogenic epithelium in rats under chronic inhalation effects of dispersible 2K orange azo dye

Gigiena truda i professional'nye zabolevaniia
S E KhipkoL N Iashina

Abstract

The article contains a morphofunctional evaluation of spermatogenic epithelium state in rats after chronic inhalation of Orange-25 disperse azo dye. The result of the study revealed gonadotoxic effects at both concentration levels 28.5 mg/m3 and 5.6 mg/m3, which manifested themselves through violations in the spermatozoa functional states and changes in the seminiferous epithelium morphometric indices. Judging from the affection of the blood, the concentration 28.5 mg/m3 can be considered toxic, and 5.6 mg/m3 can be regarded liminal. Thus, the gonadotoxic effect was a secondary one, as in male rats in both groups, a hemotoxic effect was revealed at toxic and liminal dosage concentrations.

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