PMID: 9165487Apr 1, 1997Paper

Morphochemical changes in brain structures in the course of chronic haloperidol treatment and the correction of these changes with tuftsin

Molecular and Chemical Neuropathology
L M GershteinA V Sergutina

Abstract

The systemic injection of haloperidol (4 wk, 0.5 mg/kg/d) caused the increase of protein concentration and content, and the activity level of aminopeptidase in the cytoplasm of the neurons of associated type (layer III). The nucleus of these cells decreased both in sizes and in the content of proteins. In the neurons of efferent-projectory type (layer V), the decrease of studied peculiarities as compared with control level was observed. Tuftsin (300 micrograms/kg/d) injection after chronic haloperidol treatment causes the restoring action on changed parameters in sensomotor cortex. In caudate nucleus, tuftsin influence caused further reduction of neuron's cytoplasmic area and significant reduction in protein content. The received results testify to the morphobiochemical heterogenity of investigated brain structures, which is displayed both in the case of haloperidol treatment and in the case of its correction by neuropeptide tuftsin. Chronic haloperidol administration to animals can develop a model of certain symptoms and syndromes of parkinsonism. Its most pronounced manifestation is an imbalance in the neuromediator systems, especially the dopaminergic one (Mettler and Crandall, 1959; Colls, 1984; Funk et al., 1986). The rese...Continue Reading

References

Nov 14, 1970·Nature·V A Najjar, K Nishioka
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Dec 4, 1981·Molecular and Cellular Biochemistry·K NishiokaR D Noyes
Dec 4, 1981·Molecular and Cellular Biochemistry·M Fridkin, P Gottlieb

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Citations

Aug 28, 1999·Peptides·I Z Siemion, A Kluczyk
Dec 9, 1998·Drug Metabolism Reviews·E UsukiN Castagnoli
Oct 22, 2009·Cellular and Molecular Life Sciences : CMLS·Paola GiardinaGiovanni Sannia

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