Morphoea lesions are associated with aberrant expression of membrane cofactor protein and decay accelerating factor in vascular endothelium

The British Journal of Dermatology
G T VennekerS S Asghar

Abstract

One of the main features of systemic and localized forms of scleroderma is vascular damage, the mechanism of which is not yet understood. Recently, we have shown undetectable or decreased expression of complement regulatory molecules, membrane cofactor protein (MCP) and decay-accelerating factor (DAF), in cutaneous endothelium of patients with systemic sclerosis (SSc). In some patients, CD59 expression in endothelium was also altered. As these molecules protect endothelial cells from damage by autologous complement, their decreased expression could be part of the mechanism of vascular damage in SSc. In the present study, we investigated the expression of MCP, DAF and CD59 in the endothelium of lesional and non-lesional skin of patients with localized morphoea. Normal skin and lesional skin from patients with systemic lupus erythematosus, and three inflammatory diseases, were included as relevant controls. The results showed that the extent of expression of the three molecules in non-lesional skin of patients with morphoea, on all the skin cells and structures, was identical to that of normal skin. In lesional skin, however, the expression of MCP and DAF in endothelium was either undetectable or only present to a very slight deg...Continue Reading

References

Dec 11, 1992·Clinical Immunology and Immunopathology·T V KantorT L Whiteside
Mar 1, 1992·Clinical and Experimental Dermatology·C BlackK Welsh
Mar 1, 1992·The Journal of Pathology·R J PrescottP Fielding
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·A ZimmermannH Isliker
Feb 1, 1991·Arthritis and Rheumatism·K YamaneT Masaki
Dec 1, 1990·Current Opinion in Rheumatology·R K Schachter
Sep 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·B L HsiC Grivaux
Jan 1, 1989·Annual Review of Immunology·D M Lublin, J P Atkinson
Sep 1, 1989·The Medical Clinics of North America·V Falanga
Dec 1, 1989·Journal of the American Academy of Dermatology·K KikuchiY Ishibashi

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Citations

May 20, 2003·The British Journal of Dermatology·A CosnesC Radier
Sep 1, 1999·Seminars in Cutaneous Medicine and Surgery·E Vierra, B B Cunningham
Nov 26, 1999·Journal of the American Academy of Dermatology·D N EnomotoJ D Bos

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