PMID: 8959657Nov 1, 1996Paper

Morphogenesis of degenerative changes predisposing dogs to rupture of the cranial cruciate ligament

The Journal of Veterinary Medical Science
I NaramaT Morishima

Abstract

The cranial cruciate ligaments (CCL) of 13 dogs with clinical signs of CCL rupture and those of 22 clinically healthy young beagle dogs for laboratory use were examined histopathologically and immunohistopathologically. The most constant changes at an early stage of degenerating ligament tissue in affected dogs were nuclear enlargement and perinuclear halo formation of fibrocytes followed by chondroid metaplasia. These changes were also frequent in apparently healthy young beagles kept under laboratory conditions. PAS and alcian blue positive substance accumulated around activated fibrocytes and within perinuclear halos. S-100 protein was also positive in these cells preceding the morphological change of chondroid metaplasia. Increased mitotic figures and Ki-67 positive cells showed the proliferating nature of these cells at a later stage. Alteration of extracellular matrices from dense collagen fiber type to those of cartilage tissue seemed to predispose dogs to rupture of the CCL along with a degradation in collagen fiber of the primary bundles. Collagen fiber bundles with a parallel fibrillar array never formed in the CCL with degraded primary bundles, whereas activated fibrocytes constantly underwent chondroid metaplasia. T...Continue Reading

Citations

Jul 26, 2006·Okajimas Folia Anatomica Japonica·Hiromi UedaKazushige Takehana
Jul 16, 2008·Veterinary Immunology and Immunopathology·M DoomE Cox
May 9, 1998·Journal of Comparative Pathology·M Oikawa, I Narama
Mar 26, 2014·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·L BolandO Gauthier
Jun 5, 2010·Veterinary Surgery : VS·James L Cook
Jun 15, 2006·The Veterinary Journal·Peter MuirZhengling Hao
Apr 3, 2012·The Veterinary Journal·K D SmithE J Comerford
Feb 9, 2000·The Journal of Small Animal Practice·H de Rooster, H van Bree
Sep 13, 2002·American Journal of Veterinary Research·Peter MuirZhengling Hao
Aug 21, 2003·American Journal of Veterinary Research·Kei HayashiPeter Muir
Sep 1, 2004·American Journal of Veterinary Research·Eithne J ComerfordAllen J Bailey
Sep 7, 2004·Journal of the American Animal Hospital Association·Kei HayashiPeter Muir
May 13, 2010·Veterinary Surgery : VS·Tomas InfernusoPatrick S Solt
Jul 17, 2003·Veterinary Surgery : VS·Mandi J LopezPaul A Manley
Jun 5, 2003·Veterinary Surgery : VS·Kei HayashiPeter Muir
Oct 28, 1998·Toxicologic Pathology·S SasakiH Anayama
Feb 27, 2015·The Journal of Veterinary Medical Science·Tom IchinoheYasushi Hara

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