Morphogenesis of post-Golgi transport carriers.

Histochemistry and Cell Biology
Alberto LuiniRoman S Polishchuk

Abstract

The trans-Golgi network (TGN) is one of the main, if not the main, sorting stations in the process of intracellular protein trafficking. It is therefore of central importance to understand how the key players in the TGN-based sorting and delivery process, the post-Golgi carriers (PGCs), form and function. Over the last few years, modern morphological approaches have generated new insights into the questions of PGC biogenesis, structure and dynamics. Here, we present a view by which the "lifecycle" of a PGC consists of several distinct stages: the formation of TGN tubular export domains (where different cargoes are segregated from each other and from the Golgi enzymes); the docking of these tubular domains onto molecular motors and their extrusion towards the cell periphery along microtubules; the fission of the forming PGC from the donor membrane; and the delivery of the newly formed PGC to its specific acceptor organelle. It is now important to add the many molecular machineries that have been described as operating at the TGN to this "morphofunctional map" of the TGN export process.

References

Mar 6, 1992·Cell·I Mellman, K Simons
Feb 1, 1989·The Journal of Cell Biology·G GriffithsK Simons
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·B LeitingerM Spiess
Jul 14, 1997·The Journal of Cell Biology·S I Bannykh, W E Balch
Aug 11, 1997·The Journal of Cell Biology·A A MironovA Luini
Jul 29, 1998·Histochemistry and Cell Biology·M PavelkaJ Roth
Mar 24, 1999·The Journal of Cell Biology·M S LadinskyL A Staehelin
Feb 3, 2000·Nature Cell Biology·G KreitzerE Rodriguez-Boulan
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J Lippincott-SchwartzK Hirschberg
Feb 15, 2001·Nature Cell Biology·P KellerK Simons
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·B J MarshJ R McIntosh
Sep 22, 2001·Current Biology : CB·R Jacob, H Y Naim
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Aurélien RouxPatricia Bassereau
Jan 25, 2003·Nature Cell Biology·Geri KreitzerEnrique Rodriguez-Boulan
Apr 11, 2003·Molecular Biology of the Cell·Rosa PuertollanoJuan S Bonifacino
Jun 17, 2003·Molecular Biology of the Cell·Soren MogelsvangL Andrew Staehelin
Jan 27, 2004·Nature Cell Biology·Charles YeamanVivek Malhotra
May 26, 2004·The Journal of Cell Biology·Elizabeth G CantyKarl E Kadler
Nov 3, 2004·Biochimica Et Biophysica Acta·M A De Matteis, A Godi
Nov 27, 2004·Journal of Cell Science·Sebastian Schuck, Kai Simons
Feb 4, 2005·Molecular Biology of the Cell·John G Lock, Jennifer L Stow

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Citations

Dec 1, 2009·Histochemistry and Cell Biology·Wolfgang-Moritz Heupel, Detlev Drenckhahn
Jul 13, 2013·Histochemistry and Cell Biology·Roman Polishchuk, Svetlana Lutsenko
Jun 18, 2011·Molecular Biology of the Cell·Yuliya ZilbermanAlexander Bershadsky
Jan 10, 2008·Annual Review of Cell and Developmental Biology·Benjamin S Glick, Akihiko Nakano
Dec 12, 2013·Archives of Virology·Lidia Lasecka, Michael D Baron
Oct 21, 2009·FEBS Letters·Roman S PolishchukElena V Polishchuk
Apr 10, 2015·Viruses·Makoto Ujike, Fumihiro Taguchi
Mar 16, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Foong May Yeong
May 9, 2012·Biochimica Et Biophysica Acta·Kevin D HaWilliam J Brown
Jul 8, 2010·Current Opinion in Cell Biology·Akihiko Nakano, Alberto Luini
Dec 1, 2015·Frontiers in Neuroscience·Anna A W M Sanders, Irina Kaverina
Feb 5, 2009·Traffic·Alexander LudwigPeter Sonderegger
Apr 12, 2011·Traffic·Pei Zhi Cheryl Chia, Paul A Gleeson
Feb 5, 2015·Trends in Cardiovascular Medicine·Shaohua Xiao, Robin M Shaw
Mar 17, 2010·Trends in Cell Biology·Bruno Goud, Paul A Gleeson
Nov 4, 2015·Biochimica Et Biophysica Acta·Wassim Basheer, Robin Shaw
Sep 5, 2014·Protoplasma·Delphine GendreRishikesh P Bhalerao
Jun 9, 2016·Circulation. Arrhythmia and Electrophysiology·Wassim A Basheer, Robin M Shaw
Oct 19, 2017·Scientific Reports·Lubna NadeemStephen Lye
Aug 24, 2019·Frontiers in Cell and Developmental Biology·Alexander A Mironov, Galina V Beznoussenko

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Methods Mentioned

BETA
electron microscopy

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