Morphogenesis of the respiratory bronchiole in rhesus monkey lungs

The American Journal of Anatomy
N K TylerC G Plopper

Abstract

The epithelium of the respiratory bronchiole in the adult rhesus monkey consists of two populations: a pseudostratified epithelium with basal, mucous goblet, and ciliated cells located near the pulmonary artery (PA); and a simple cuboidal epithelium composed only of nonciliated bronchiolar epithelial (or Clara) cells in areas away from the PA. This study describes the pattern of differentiation of these two epithelial populations, and their relationship to the PA and to the time of appearance of alveoli in the respiratory bronchiole of the rhesus monkey during the period of 90-125 days gestational age (DGA). These events were related to changes in the adjacent parenchyma. Dissected airways of infusion-fixed, critical-point-dried lungs were evaluated by scanning microscopy followed by light microscopy of the same airways. At 54% of gestation (90 DGA), the distal airway was lined by a mixture of ciliated and nonciliated cells. By 67% of gestation (110 DGA), the ciliated cells were confined to the epithelium over the PA. The underlying connective tissue initially was cellular containing few fibers but was fibrous by 76% of gestation (125 DGA). Alveolarization began near the most distal cartilage at 57% of gestation (95 DGA), the s...Continue Reading

References

May 1, 1979·Human Pathology·B T Smith, W A Fletcher
Sep 25, 1975·Anatomy and Embryology·A J Collet, G Des Biens
May 1, 1976·Journal of Ultrastructure Research·J G BlueminkK A Lawson
Mar 1, 1987·Respiration Physiology·T B ZeltnerP H Burri
Mar 1, 1987·Respiration Physiology·T B Zeltner, P H Burri
Mar 1, 1985·The Anatomical Record·N K Tyler, C G Plopper
Nov 1, 1985·The Anatomical Record·E M McDowellB Coleman
Jul 1, 1974·The Anatomical Record·A J Collet, G Des Biens
Sep 1, 1974·The Anatomical Record·S L KauffmanE R Weibel
Sep 1, 1974·The Anatomical Record·P H Burri
Apr 1, 1974·The Anatomical Record·P H BurriE R Weibel
Jan 1, 1974·Thorax·A Hislop, L Reid
Jan 1, 1965·Acta Anatomica·E A Boyden, D H Tompsett
Sep 1, 1984·The American Journal of Physiology·G D MassaroD Massaro
Jun 1, 1983·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·S Kawamata, H Fujita
Jan 15, 1984·American Journal of Obstetrics and Gynecology·T E Bunton, C G Plopper
Jul 1, 1983·The American Review of Respiratory Disease·P E EnterlineN A Esmen
Jul 1, 1983·The American Journal of Anatomy·D M HydeJ L Alley
Jan 1, 1961·Acta Anatomica·E A BOYDEN, D H TOMPSETT

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Citations

Nov 1, 1995·Pediatric Pulmonology·D W ThibeaultM M Rezaiekhaligh
Mar 22, 2005·Cell and Tissue Research·Harmanjatinder S SekhonEliot R Spindel
Apr 25, 2000·Respiration Physiology·A Barbier, H Bachofen
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·H WitschiK E Pinkerton
Dec 1, 1991·Anatomia, histologia, embryologia·M S al-TikritiW C Cullens
Jan 1, 1997·In Vitro Cellular & Developmental Biology. Animal·M Emura
Mar 15, 2008·Pulmonary Pharmacology & Therapeutics·Charles G Plopper, Dallas M Hyde
Oct 31, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·John T CoppensLaura S Van Winkle
Jul 1, 1989·Differentiation; Research in Biological Diversity·T H HuangR Wu
Dec 22, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·J E LarsonJ C Cohen
Feb 2, 2017·Cell and Tissue Research·Johannes C Schittny
May 4, 2017·Anatomia, histologia, embryologia·F ArodakiM Al-Tikriti
May 2, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michelle V FanucchiEdward S Schelegle

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