Morphogenesis of the somatic musculature in Drosophila melanogaster

Wiley Interdisciplinary Reviews. Developmental Biology
Victoria K SchulmanMary K Baylies

Abstract

In Drosophila melanogaster, the somatic muscle system is first formed during embryogenesis, giving rise to the larval musculature. Later during metamorphosis, this system is destroyed and replaced by an entirely new set of muscles in the adult fly. Proper formation of the larval and adult muscles is critical for basic survival functions such as hatching and crawling (in the larva), walking and flying (in the adult), and feeding (at both larval and adult stages). Myogenesis, from mononucleated muscle precursor cells to multinucleated functional muscles, is driven by a number of cellular processes that have begun to be mechanistically defined. Once the mesodermal cells destined for the myogenic lineage have been specified, individual myoblasts fuse together iteratively to form syncytial myofibers. Combining cytoplasmic contents demands a level of intracellular reorganization that, most notably, leads to redistribution of the myonuclei to maximize internuclear distance. Signaling from extending myofibers induces terminal tendon cell differentiation in the ectoderm, which results in secure muscle-tendon attachments that are critical for muscle contraction. Simultaneously, muscles become innervated and undergo sarcomerogenesis to es...Continue Reading

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Citations

Jul 18, 2016·Seminars in Cell & Developmental Biology·Eyal D Schejter
Sep 14, 2016·Current Biology : CB·Ingo Bothe, Mary K Baylies
Jun 12, 2018·PLoS Computational Biology·Angelika ManhartAlex Mogilner
Jul 30, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nagaraju DhanyasiEyal D Schejter
Nov 30, 2019·Skeletal Muscle·Erika R Geisbrecht, Mary K Baylies
Dec 3, 2020·Molecular Biology Reports·Madhavi DubeyHena Firdaus
Aug 18, 2020·Toxicology·Ashley E PeppriellMatthew D Rand
Sep 22, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jakob T GundersonMatthew D Rand
Feb 20, 2020·Seminars in Cell & Developmental Biology·Elena NikonovaMaria L Spletter

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