Morphogenetic fields of embryonic development in locoregional cancer spread

The Lancet Oncology
Michael Höckel

Abstract

The ontogenetic theory of locoregional cancer spread regards cancer as a clinical manifestation of the pathological reactivation and maintenance of the sequential developmental programmes that previously controlled the stepwise embryological morphogenesis of the tissue from which the cancer originated. In the state of morphostasis that characterises adult organisms, these programmes are silenced. During malignant progression, these programmes run in retrograde sequence, which leads to cancer infiltration of ever larger tissue areas. However, because the reactivated morphogenetic programmes need topologically defined tissue domains--morphogenetic fields--to provide positional information for their interpretation, local tumour propagation is confined to permissive compartments (topographically defined tissue domains where malignant cells can survive, migrate, and proliferate), which are determined by the state of malignant progression. The tissue at risk of local tumour spread, the cancer field, is the mature tissue derived from the corresponding morphogenetic field in the embryo, which is labelled with the respective positional information. The theory can be tested morphologically and clinically for all tumours. Verification of ...Continue Reading

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Citations

Apr 17, 2016·Insights Into Imaging·Inês A SantiagoRichard J Heald
May 20, 2016·Case Reports in Surgery·Tayfun ToptasTayup Simsek
Apr 26, 2016·Journal of Minimally Invasive Gynecology·Giuseppe VizzielliVito Chiantera
Dec 8, 2017·NMR in Biomedicine·Claudia Tanja MierkeJosef Alfons Käs
May 18, 2018·Journal of Gynecologic Oncology·Rainer Kimmig, Thomas Ind
Sep 6, 2019·Scientific Reports·Hans KubitschkeJosef Käs
Apr 3, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nadeem R Abu-RustumOliver Zivanovic
Jun 27, 2018·Chinese Medical Journal·Lei LiMing Wu
Jun 14, 2019·Frontiers in Oncology·Michael Höckel, Ulrich Behn
Oct 9, 2020·Signal Transduction and Targeted Therapy·Siyuan QinWeifeng He

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