Morphogenetic plasticity of neuronal elements in cerebellar glomeruli during deafferentation-induced synaptic reorganization

Journal of Neural Transplantation & Plasticity
J HámoriJ Takacs

Abstract

Reorganization of the cerebellar glomerulus, the main synaptic complex within the granule cell layer, was investigated using quantitative morphological techniques. All afferents to the cerebellar cortex, including mossy-fibers, were surgically destroyed by undercutting the cerebellar vermis. Fifteen days after the operation, which resulted in the removal of the main excitatory afferent to the glomerulus, a significant reorganization of the whole synaptic complex was observed, whereas the structural integrity of the glomerulus was remarkably well preserved. This was indicated by the observation that the number of granule cell dendrites (approximately 50 per glomerulus), as well as the number of dendritic digits (approximately 210 per glomerulus) bearing most of the approximately 230 synaptic junctions per glomerulus, did not change significantly after mossy-fiber degeneration. The total number of synapses in the reorganized glomerulus did not change either, despite the disappearance of two-thirds of (excitatory) synaptic junctions caused by mossy-fiber degeneration. In the reorganized glomeruli, however, the inhibitory, GABA-containing Golgi axonal varicosities became the dominant synaptic type-about four-fifths (approximately 2...Continue Reading

Citations

Sep 3, 2011·Journal of Theoretical Biology·Cassie S Mitchell, Robert H Lee
Mar 6, 2002·The European Journal of Neuroscience·Ronald S PetraliaRobert J Wenthold
Jul 2, 1999·Stroke; a Journal of Cerebral Circulation·H YamauchiJ Konishi
Oct 27, 2004·Transplantation·Megan SykesUNKNOWN IXA Ethics Committee
Sep 18, 2007·Journal of Neural Engineering·Cassie S MitchellRobert H Lee

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