Morphogengineering roots: comparing mechanisms of morphogen gradient formation.

BMC Systems Biology
Verônica A GrieneisenAthanasius F M Marée

Abstract

In developmental biology, there has been a recent focus on the robustness of morphogen gradients as possible providers of positional information. It was shown that functional morphogen gradients present strong biophysical constraints and lack of robustness to noise. Here we explore how the details of the mechanism which underlies the generation of a morphogen gradient can influence those properties. We contrast three gradient-generating mechanisms, (i) a source-decay mechanism; and (ii) a unidirectional transport mechanism; and (iii) a so-called reflux-loop mechanism. Focusing on the dynamics of the phytohormone auxin in the root, we show that only the reflux-loop mechanism can generate a gradient that would be adequate to supply functional positional information for the Arabidopsis root, for biophysically reasonable kinetic parameters. We argue that traits that differ in spatial and temporal time-scales can impose complex selective pressures on the mechanism of morphogen gradient formation used for the development of the particular organism.

References

Nov 1, 1977·Biophysical Journal·H C Berg, E M Purcell
Jan 1, 1990·Journal of Cell Science. Supplement·L Wolpert
Jul 1, 1988·Cell·W Driever, C Nüsslein-Volhard
Oct 1, 1969·Journal of Theoretical Biology·L Wolpert
Aug 29, 1973·Nature: New Biology·P H Rubery, A R Sheldrake
Jan 31, 1970·Nature·F Crick
Sep 1, 1968·The Journal of General Physiology·R C BeanH Chan
Sep 28, 1968·Nature·M B Wilkins, T K Scott
Feb 1, 1967·Plant Physiology·M H Goldsmith
Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Aug 21, 1980·The Journal of Membrane Biology·J Gutknecht, A Walter
Dec 1, 1996·Current Biology : CB·M Estelle
Aug 14, 1999·Science·F G Giancotti, E Ruoslahti
Jan 19, 2000·Trends in Genetics : TIG·F Pagès, S Kerridge
Mar 11, 2000·Plant Physiology·N M KerkL J Feldman
Feb 13, 2001·Current Opinion in Plant Biology·T Berleth, T Sachs
Jul 13, 2001·Current Opinion in Genetics & Development·V F Irish, P D Jenik
Dec 4, 2001·Genes & Development·P W Ingham, A P McMahon
Sep 12, 2002·EMBO Reports·Didier Reinhardt, Cris Kuhlemeier
Nov 28, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jeremy Green
Oct 11, 2003·Developmental Cell·Avigdor EldarNaama Barkai
Nov 14, 2003·Nature·Stefan Kepinski, Ottoline Leyser
Jul 21, 2004·Current Opinion in Genetics & Development·Avigdor EldarNaama Barkai
Sep 1, 2004·Current Opinion in Plant Biology·Thomas BerlethEnrico Scarpella
Oct 30, 2004·Science·Nicholas J Kaplinsky, M Kathryn Barton
Nov 27, 2004·Trends in Plant Science·Eric M Kramer
Feb 9, 2005·Physical Review Letters·T BollenbachF Jülicher
Mar 24, 2005·Physical Review Letters·Jeremy L England, John Cardy
Jul 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·William Bialek, Sima Setayeshgar
Aug 2, 2005·Current Opinion in Plant Biology·Joshua J BlakesleeAngus S Murphy
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Thomas GregorEric F Wieschaus
Dec 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·C Alex EsmonEmmanuel Liscum
Jan 21, 2006·Science·Jian XuBen Scheres
Feb 3, 2006·Development·Krishanu Saha, David V Schaffer
Feb 16, 2006·The International Journal of Developmental Biology·Donald E Ingber

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Citations

Oct 16, 2012·Science·Anna KichevaJames Briscoe
Feb 28, 2014·Proceedings. Biological Sciences·Giuseppe FuscoNigel C Hughes
Apr 22, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Su SuAlicia M Fry
Mar 19, 2014·The Plant Cell·Leah R BandMalcolm J Bennett
Jul 23, 2013·Journal of Integrative Plant Biology·Verônica A GrieneisenLars Ostergaard
Nov 30, 2013·Physiologia Plantarum·Rishikesh P Bhalerao, Urs Fischer
Feb 6, 2014·Physiologia Plantarum·Tatsuaki GohAnthony Bishopp
Mar 26, 2015·Trends in Plant Science·John William Chandler, Wolfgang Werr
Jan 18, 2014·Trends in Plant Science·Rosangela SozzaniPhilip N Benfey
Jan 31, 2015·Current Opinion in Plant Biology·Rucha Karve, Anjali S Iyer-Pascuzzi
Jul 30, 2014·Frontiers in Plant Science·Natalie M ClarkRosangela Sozzani
Apr 14, 2016·Annals of Botany·Katie AbleyH M Ottoline Leyser
Sep 17, 2013·Journal of Proteome Research·Benedetta MatteiM Eugenia Schininà
Mar 6, 2018·Annual Review of Plant Biology·Lilan HongAdrienne H K Roeder
Jan 13, 2018·Molecular Systems Biology·Irina PavelescuMarta Ibañes
Aug 24, 2017·Proceedings of the National Academy of Sciences of the United States of America·Riccardo Di MambroSabrina Sabatini
Nov 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Juan-José RipollAdrienne H K Roeder
Jul 27, 2017·Frontiers in Plant Science·Gen SakuraiJian Feng Ma
Apr 10, 2019·Nature Reviews. Molecular Cell Biology·Mariano BizzarriMichael Levin
Nov 7, 2017·Developmental Cell·Damianos S SkopelitisMarja C P Timmermans
Apr 16, 2021·Frontiers in Plant Science·Nicolas LevernierYoël Forterre

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