Morphologic and biochemical features affecting the antithrombotic properties of the inferior vena cava of rabbit pups and adult rabbits

Pediatric Research
E NitschmannM Andrew

Abstract

The incidence of venous thromboembolic disease is reduced in children compared with adults. Thromboprotective mechanisms, some of which have already been identified in plasma, must be present in children. Blood vessel walls have important antithrombotic properties that maintain blood fluidity. This is in part due to proteoglycan (PG)-related glycosaminoglycan (GAG) molecules within vessel walls. PGs are macromolecules with covalently attached GAG chains, either chondroitin, dermatan, heparan, or keratan sulfate. The influence of age on the concentration and anticoagulant activities of PGs and GAGs, within vein walls before puberty has not been previously investigated. We hypothesized that developmental differences in vein walls may contribute to the reduced risk of thrombosis in children. We used a rabbit model to examine morphologic and biochemical features of inferior venae cavae (IVCs). We assessed IVC wall morphology, PG distribution, GAG mass, and GAG antithrombin activity. Morphologically, there were only minor differences between pups and adult rabbits' IVCs. However, there was a significant increase in GAGs by mass in IVCs from pups compared with adult rabbits (p = 0.012). In addition the total antithrombin activity (p ...Continue Reading

References

Jan 1, 1990·The American Journal of Pediatric Hematology/oncology·M AndrewM Johnston
Apr 1, 1985·Experimental and Molecular Pathology·G R Campbell, J H Campbell
Jul 1, 1967·The Journal of Pediatrics·L A Monnens, R J Retera
Apr 1, 1993·Experimental and Molecular Pathology·M Richardson, M W Hatton

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Citations

Nov 15, 2013·Circulation·Therese M GigliaUNKNOWN American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council
Jan 12, 2021·Seminars in Thrombosis and Hemostasis·Yona Nadir, Benjamin Brenner
Nov 9, 2015·Journal of Pediatric Surgery·Casey J AllenKenneth G Proctor
Apr 2, 2021·Seminars in Thrombosis and Hemostasis·Yona Nadir

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