PMID: 9553811Apr 29, 1998Paper

Morphologic and immunophenotypic characterization of foam cells in endometrial lesions

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
S A Silver, M E Sherman

Abstract

The detection of foam cells in cervicovaginal smears obtained from postmenopausal women suggests the possibility of an endometrial lesion. Ultrastructural studies have suggested that foam cells represent endometrial stromal cells but the histogenesis of these cells has not been firmly established. To investigate the origin and diagnostic significance of foam cells, we analyzed the morphology and immunophenotype of these cells in endometrial tissue specimens and correlated the findings with cervical smears obtained within the preceding 6 months. Selected biopsies containing foam cells were evaluated using four well-characterized macrophage markers: KP-1(CD68), HAM 56, MAC 387, and lysozyme. Foam cells were found in 11 (38%) of 29 simple hyperplasias, 7 (50%) of 14 complex hyperplasias, 6 (50%) of 12 complex atypical hyperplasias, 21 (70%) of 30 adenocarcinomas, 1 (4%) of 25 samples with stromal breakdown, and 0 of 30 specimens showing normal cycling endometrium. Foam cells were also found in smears preceding the histologic diagnosis of 2 (13%) simple hyperplasias, 2 (25%) complex hyperplasias, 3 (43%) complex atypical hyperplasias, 5 (28%) adenocarcinomas, 5 (28%) cases of stromal breakdown, and 0 of 8 normal tissue specimens ex...Continue Reading

Citations

Apr 25, 2006·Journal of Lower Genital Tract Disease·David L GreenspanAnn T Moriarty
Feb 10, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Michael A Dimaio, Teri A Longacre
Dec 5, 2013·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Vinita ParkashOluwole Fadare
Nov 17, 2007·Diagnostic Cytopathology·John A MaksemStanley J Robboy
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S G Silverberg
Feb 28, 2003·Histopathology·D Suárez-Vilela, F M Izquierdo-García
Dec 19, 2012·Reproduction, Fertility, and Development·D Claire WathesGeoff E Pollott
Mar 15, 2021·Annales de pathologie·Quitterie Fontanges
Jun 30, 2021·Current Opinion in Obstetrics & Gynecology·Katherine ChavesMirna Podoll

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