PMID: 3770145Oct 1, 1986Paper

Morphologic and microbiologic features of Pseudomonas aeruginosa pneumonia in normal hamsters

Experimental and Molecular Pathology
J J CoalsonW G Johanson

Abstract

A model of pneumonia due to Pseudomonas aeruginosa was produced in hamsters by an intratracheal bolus instillation of microorganisms. Sequential lung changes from 4 hr through 11 days were studied by morphologic and microbiologic methods. Hamsters inoculated with greater than 10(6) pseudomonads survived but consistently had histologic evidence of mild bronchopneumonia 24 hr postinoculation, whereas a severe bronchopneumonia and a 100% mortality were elicited with a 10(8) inoculum of organisms in 0.5 ml phosphate-buffered saline (PBS). An inoculum of 10(7) pseudomonads/0.5 ml PBS was then used to define the changes in the bacterial population in Pseudomonas pneumonia and to obtain serial histopathologic observations. Quantitative lung cultures obtained within 1 hr postinoculation demonstrated a mean of 10(6) colony forming units per lung, and none of the hamsters were bacteremic. However, by 24 hr bacterial counts had increased and all animals were bacteremic. Bacterial proliferation continued through 48 hr; however, the number of bacteremic animals had decreased. By 72 hr, bacterial counts had decreased with total Pseudomonas clearance noted by 120 hr. A striking polymorphonuclear leukocyte-rich alveolar exudate was present by ...Continue Reading

References

Jun 1, 1978·The Journal of Infectious Diseases·J E Pennington, M G Ehrie
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Sep 1, 1982·The Journal of Surgical Research·G A Patterson, T R Todd

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Citations

May 1, 1995·Intensive Care Medicine·G U Meduri, R J Estes
Jan 27, 2009·Current Gastroenterology Reports·Einar Björnsson
Jan 24, 2004·Intensive Care Medicine·Frédérique SchortgenGeorges Saumon
Jun 16, 2001·Journal of Applied Physiology·H SuzukiI Rubinstein

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