Morphologic and neurochemical target selectivity of regenerating adult photoreceptors in vitro

The Journal of Comparative Neurology
David M SherryE Townes-Anderson

Abstract

Regenerating adult central nervous system (CNS) neurons must re-establish synaptic circuits in an environment very different from that present during development. However, the complexity of CNS circuitry has made it extremely difficult to assess the selectivity and mechanisms of synaptic regeneration at the cellular level in vivo. The synaptic preferences of adult photoreceptors were examined by using a defined cell culture system known to support regenerative process growth, presynaptic varicosity formation, and establishment of functional synapses. Immunolabeling for synaptic vesicle protein 2 and ultrastructural analysis demonstrated that cell-cell contacts made by photoreceptors were synaptic in nature. Target selectivity was determined by quantitative analysis of contacts onto normal and novel target cell types in cultures in which opportunities to contact all retinal cell types were present. Target cells were identified by morphology and immunolabeling for the amino acid neurotransmitters glutamate, aspartate, gamma-aminobutyric acid (GABA), and glycine. Regenerating photoreceptors showed a strong preference for novel multipolar cell targets (amacrine and ganglion cells) over normal photoreceptor, horizontal, and bipolar ...Continue Reading

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Citations

Jun 22, 2000·The Journal of Comparative Neurology·J LevensonA Eskin
Jan 24, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Frank KungEllen Townes-Anderson
Jan 25, 2002·The Journal of Comparative Neurology·Haidong YangDavid M Sherry
May 8, 2007·Progress in Retinal and Eye Research·Carl Romano, David Hicks

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