PMID: 6109470Jan 1, 1981Paper

Morphologic changes in mouse spermatozoa after exposure to inhalational anesthetics during early spermatogenesis

Anesthesiology
P C LandH W Linde

Abstract

The authors studied anesthetic mutagenesis following exposure in vivo by use of an adaptation of the mouse spermatozoa morphology assay of Wyrobek and Bruce. The epididymal spermatozoa of (C57B1/C3H)F1 mice were examined for morphologic abnormalities following exposure to near-0.1 MAC and greater concentrations of general anesthetics. Twenty exposure hours (4 hr/day x 5 days) were conducted for nitrous oxide, diethyl ether, chloroform, trichlorethylene, halothane, methoxyflurane, enflurane, and isoflurane, each at two concentrations. Twenty-eight days after exposure, epididymal spermatozoa were examined. Statistically significant increases in the percentages of abnormal spermatozoa were found for chloroform, trichloroethylene, and enflurane, compared with controls. These data suggest that direct examination of reproductive cells following exposure to general anesthetics in vivo may be useful in the investigation of the genetic toxicities of these compounds.

Citations

Nov 1, 1995·Mutation Research·R FahrigH Baumann
Jan 1, 1991·Reproductive Toxicology·G K LemastersS Clark
Jan 1, 1982·Experimental Pathology·W D Pope, T V Persaud
Jan 1, 1985·Journal of Toxicology and Environmental Health·R D KimbroughV N Houk
Jan 23, 2004·Biology of Reproduction·Shelley Brown DuTeauxMarion G Miller
Feb 1, 1992·Acta Anaesthesiologica Scandinavica·B N AndersenJ P Johansen
Aug 4, 2001·Environmental Health Perspectives·H Y ChangY L Guo
Nov 1, 1986·Environmental Health Perspectives·M K SmithE L George
Dec 10, 1999·Environmental Health Perspectives·N B MunroV Hauschild
Jan 1, 1987·Reproductive Toxicology·D N Buckley, J B Brodsky
Jul 1, 1989·Mutation Research·R Crebelli, A Carere
May 1, 1996·Critical Reviews in Toxicology·S TasD Lison
Mar 15, 1983·Toxicology and Applied Pharmacology·R I MazzeJ M Baden
Jan 1, 1987·Environmental and Molecular Mutagenesis·S L Rosenthal
Nov 14, 1997·Regulatory Toxicology and Pharmacology : RTP·R J GoldenE A Reese
Feb 4, 2011·Animal Reproduction Science·E JiménezE Agüera
Oct 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Osamu TakahashiAkio Ogata
May 18, 2016·Regulatory Toxicology and Pharmacology : RTP·John FrangosChristin Down
May 2, 2003·Biology of Reproduction·Shelley Brown DuTeauxMarion G Miller
Apr 3, 2002·Human & Experimental Toxicology·P KumarK K Dutta
Jan 1, 1991·American Journal of Industrial Medicine·B EskenaziD M Rempel
Jan 1, 1991·American Journal of Industrial Medicine·M A McDiarmidR Duffy
Jul 27, 2020·Environmental Epigenetics·Jill Escher, La Donna Ford
Sep 1, 1986·Medical Toxicology·J B Brodsky, E N Cohen
Oct 2, 2021·Journal of Autism and Developmental Disorders·Jill EscherVictor G Corces

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.