Morphologic changes in offspring of female mice exposed to ethanol before conception

American Journal of Obstetrics and Gynecology
B A SoltesE Radwanska

Abstract

Our purpose was to evaluate the mutagenic effects of preconceptional ethanol exposure by use of the mouse model. Fifty-three adult female CF-1 mice were divided into one of five groups with or without an ethanol diet for 28 days. Mice were then superovulated and mated. On day 14 of gestation all mice were killed and fetuses removed and examined for abnormalities. The mutation index for the study and mutagen groups was similar (48% vs 41%). The percentage of any anatomic abnormality in any treatment group were between 50% and 100%. Anomalies of the abdominal wall were most commonly seen in the mutagenic groups. Chronic ethanol exposure in the female mouse before conception yields anatomic abnormalities in the offspring. These mutagenic effects may be variable in that they may result in a dominant lethal mutation or a delayed interference with organogenesis. Ethanol consumption, whether before or after conception, poses an unfavorable outcome in the offspring produced.

References

Dec 1, 1979·Mutation Research·G Obe, H Ristow
Oct 1, 1990·Alcoholism, Clinical and Experimental Research·S SchenkerG I Henderson
May 1, 1987·Journal of Reproduction and Fertility·J L Wiebold, W C Becker
Nov 3, 1973·Lancet·K L Jones, D W Smith

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Citations

Feb 19, 2011·Cell Biology and Toxicology·Elisa CebralMarta Dolores Mudry
Sep 17, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Tamara A CollElisa Cebral
Sep 23, 2014·Congenital Anomalies·Mireya Robledo-AcevesJorge Román Corona-Rivera

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