PMID: 6539238Jan 1, 1984Paper

Morphologic changes of the esophageal mucosa in the rat after chronic alcohol ingestion

Experimental Pathology
C MascrèsJ G Joly

Abstract

Fifteen litter-matched pairs of Sprague-Dawley rats were divided into two groups, one fed an alcoholic diet and the other fed an isocaloric but non-alcoholic diet. 5 animals each of the experimental and control groups were sacrificed at 98, 200 and 290 d. The upper part of esophagus was fixed for morphological analysis of semi-fine sections. The following histological observations were made on the oral-esophageal mucosa of the alcohol-consuming animals: An epithelial atrophy was observed between 200 and 290 d of alcoholisation . This atrophy was not the result of a decrease in the number of epithelial layers, but was associated with a decrease in basal cellular size. A basal cell pleomorphism and a tendency towards epithelial dysplasia were the rule after long time alcohol consumption. These observations reflect features resembling to those seen in Plummer- Vinson syndrome, a precancerous state in humans.

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Citations

Sep 1, 1985·Digestive Diseases and Sciences·M A KorstenQ Federman
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·Frank RiedelKarl Hörmann
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May 5, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G R OgdenP Rice

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