PMID: 2109103Apr 1, 1990Paper

Morphologic characteristics of adsorbed human plasma proteins on vascular grafts and biomaterials

Journal of Vascular Surgery
D A PankowskyJ M Anderson

Abstract

Protein adsorption on the surfaces of clinically significant prosthetic vascular graft materials from human whole blood was independent of plasma concentration as determined morphologically by use of immunogold labels. Some proteins, such as fibrinogen, adsorbed in a multilayer pattern on expanded polytetrafluoroethylene and had a preference for particular surface features of the polymer. Other proteins, such as Hageman factor (factor XII), showed diffuse adsorption patterns. Physiologically significant proteins that have not been well studied, such as immunoglobulin G and factor VIII, adsorbed readily to the surface of expanded polytetrafluoroethylene. This finding may be significant since adsorbed proteins may activate coagulation mechanisms and immunologic responses, including platelet and monocyte adhesion and activation. Any human blood protein for which an antibody has been developed can be studied by use of this technique.

Citations

Aug 8, 2006·Tissue Engineering·Daniël T LuttikhuizenMarja J A Van Luyn
Jan 1, 1993·Journal of Cardiac Surgery·P ZillaM Deutsch
Nov 26, 2010·Journal of Biomedical Materials Research. Part a·Angela M B ColliePatrick S Stayton
Apr 25, 2013·Journal of Biomedical Materials Research. Part a·Ryan J Love, Kim S Jones
Sep 22, 2009·Journal of Biomedical Materials Research. Part a·Haoqing CaoJames M Anderson
Jun 1, 2000·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D FalkenbackA Ljungh
Feb 5, 2013·Acta Biomaterialia·M BinazadehL D Unsworth
Mar 29, 2002·Journal of Biomedical Materials Research·T O Collier, J M Anderson
Dec 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Z ZdanowskiC Schalén

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.