Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model

Drug Metabolism Letters
Richard A PetersonMark De Serres

Abstract

Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio (uPA(+/+)/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.

Citations

Nov 21, 2015·Chemical Research in Toxicology·Eric Blomme, Yvonne Will
Nov 30, 2012·International Journal of Hepatology·Isabelle Vidal, Lysiane Richert
Dec 18, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shigeyuki Kitamura, Kazumi Sugihara
Mar 5, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Mark De SerresCosette Serabjit-Singh

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