Abstract
The diameters of the ascending aorta, coronary ostia, and proximal coronary arteries were measured in autopsy specimens from 51 infants with hypoplastic left heart syndrome and 18 normal infant heart specimens. Standard cross sections were prepared from 35 of the hypoplastic left heart syndrome hearts, and histologic indices of myocardial viability and fibrosis were determined. The diameters of the coronary arteries and ostia in hypoplastic left heart syndrome were not different from the values in control specimens. Little fibrosis was found but extensive myocardial necrosis was present. The degree of fibrosis and necrosis did not correlate significantly with any of the arterial or ostial diameters. The extent of myocardial preservation in the hypoplastic left heart syndrome, which may substantially limit the success of surgical palliation, cannot be predicted from these morphologic measurements. The observed myocardial damage appeared to be acquired postnatally, implying that early vigorous treatment of these infants may be necessary to preserve myocardial function.
References
Dec 20, 1985·JAMA : the Journal of the American Medical Association·L L BaileyW B Jolley
Feb 1, 1986·Journal of the American College of Cardiology·M EhrlichW M Gersony
Oct 1, 1972·The Annals of Thoracic Surgery·S B LitwinW F Bernhard
Jan 1, 1967·Circulation·H E MacMahon, P C Dickinson
Nov 1, 1982·Circulation·W N O'ConnorJ A Noonan
Oct 1, 1980·Circulation·M D CheitlinM Lev
Citations
Mar 23, 2013·Pediatric Cardiology·Jeffrey H Shuhaiber, Frank A Pigula
Aug 1, 1992·Journal of the American College of Cardiology·J M BaffaP M Weinberg
Mar 1, 1989·Pediatric Neurology·D M Olson, D A Shewmon
Sep 6, 2011·Radiologic Clinics of North America·L P BrowneT Chung
Jul 15, 2015·Cardiology in the Young·Charles R Cole, Pirooz Eghtesady
Jun 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·André M IlbawiRobert H Anderson
May 9, 2006·The Journal of Thoracic and Cardiovascular Surgery·Jürgen StiehHans Heiner Kramer
Mar 3, 2004·The Annals of Thoracic Surgery·Caner SalihSiew Yen Ho
Apr 14, 2012·The Journal of Thoracic and Cardiovascular Surgery·Meena NathanAmy L Juraszek
Oct 1, 1986·American Heart Journal·T A Riemenschneider
Jul 1, 1989·The Annals of Thoracic Surgery·R A GustafsonG E Rozar
May 16, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·D M BardoR P Saneto
Aug 29, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nelson AlphonsoJohn M Simpson