Morphologic Features of Gastric-type Cervical Adenocarcinoma in Small Surgical and Cytology Specimens

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Gulisa TurashviliRajmohan Murali

Abstract

Gastric-type cervical adenocarcinoma (GCA) is a human papillomavirus-unassociated, aggressive, chemorefractory tumor. Well-differentiated examples may exhibit bland morphologic appearances, which could potentially lead to misdiagnosis, particularly in limited material. We sought to characterize the morphologic features of GCA in surgical biopsy and cytology specimens. We identified patients with histologic diagnoses of GCA or minimal-deviation adenocarcinoma between 2004 and 2017. Available slides from biopsy, curettage, and cytology specimens were reviewed. Fifty-nine specimens (37 histology, 22 cytology) were reviewed from 23 patients, including histology specimens alone from 6 patients, cytology specimens alone from 4 patients, and both types of specimen from 13 patients. The median patient age was 52 yr (range, 29-83 yr). Biopsies showed well-to-moderately differentiated adenocarcinomas composed of cells with pale or foamy cytoplasm and well-defined cytoplasmic borders. Nuclei exhibited mild-to-moderate pleomorphism with small nucleoli. The diagnosis was challenging in a minority of biopsies in which neoplastic glandular epithelium was scant, fragmented, and/or well differentiated. Cytology slides showed single and crowded ...Continue Reading

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Citations

Apr 26, 2019·Histopathology·Anjelica HodgsonJelena Mirkovic
Aug 28, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Nancy Y GreenlandPoonam Vohra
Oct 29, 2020·Der Pathologe·Irena Baltisser
Sep 11, 2020·The American Journal of Surgical Pathology·Gulisa TurashviliLars-Christian Horn
Dec 16, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Pier SelenicaRajmohan Murali
Jun 3, 2021·Diagnostics·Francesca ArezzoEttore Cicinelli
Oct 23, 2020·Archives of Pathology & Laboratory Medicine·Laurie M GriesingerStephanie L Skala
Dec 15, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Sushmita B GordhandasJennifer J Mueller

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Methods Mentioned

BETA
biopsies
biopsy
hysterectomy

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