PMID: 11908867Mar 23, 2002Paper

Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system: histological heterogeneity and surgical meaning

Brain Tumor Pathology
K SugiyamaK Kurisu

Abstract

Our study of germ cell tumors (GCT) of the central nervous system (CNS) investigated the relationship between tumor histology and patient serum titers of human chorionic gonadotropin (HGC) and alpha-fetoprotein (AFP). Thirty-five patients were enrolled. Their serum titers of HCG (mlU/ml) and/or AFP (ng/ml) before initial treatment were available, as were tumor specimens obtained before the administration of adjuvant therapy. They were divided into three groups, depending on whether HCG alone (group H), AFP alone (group A), or both HCG and AFP (group HA) were detected. Each group was subdivided into three groups: patients in group I had H, A, and/or HA titers below 9.9; patients in group II/III had titers from 10.0 to 999; and those in group IV had titers of 1000 or more. Serial sections of tissue specimens were repeatedly stained, mainly with hematoxylin and eosin (H-E) stain, HCG immunostain, and AFP immunostain. There were seven patients in the H-I group and five in H-II/III. Of these 12 patients, 11 had germinomas (G) and one had an embryonal carcinoma (EC). Five patients were included in group A: one was classified as A-II/III and had a germinoma, and the remaining four patients were in A-IV and had yolk sac tumors (YST) or...Continue Reading

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Citations

Apr 7, 2006·Journal of Neuro-oncology·Neal LutherMark M Souweidane
Feb 20, 2010·Neuro-oncology·J Lee VillanoBridget J McCarthy
May 27, 2014·Neuro-Chirurgie·C Faure-Conter
Jun 1, 2018·Journal of Child Neurology·Ziren KongYu Wang
Jun 18, 2021·Journal of Neuroendocrinology·Emilia SbardellaUNKNOWN Talent group

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