Morphologic fluorescein angiographic, and light microscopic features of experimental choroidal neovascularization

American Journal of Ophthalmology
D B Archer, T A Gardiner

Abstract

We induced choroidal neovascularization in the rhesus monkey by impoverishing the blood supply to the inner retina and producing defects in Bruch's membrane by photocoagulation. Fourteen of 46 eyes undergoing photocoagulation developed neovascular fronds which were identified and categorized by histopathologic examination and fluorescein angiography. All new vessels gained access to the retina through defects in Bruch's membrane at the site of photocoagulation marks. In eight eyes the new vessels remained localized to the immediate vicinity of photocoagulation marks. In four eyes neovascular fronds infiltrated the subretinal space for distances up to 6 disk diameters from the point of entry into the retina. In the two eyes choroidovitreal neovascular complexes developed but rapidly regressed shortly after gaining the vitreous cavity. Fluorescein angiography demonstrated that all neovascular fronds were grossly incompetent to dye but that formed feeding channels had some degree of integrity. Light microscopic studies showed the proliferating networks to be composed of capillaries with well-formed basement membranes and more mature vessels with the basic structure of choroidal arteries and veins.

Citations

Feb 1, 1983·International Ophthalmology·D B Archer, T A Gardiner
Jan 1, 1982·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·N T Versteeg-TijmesH M vd Horst-Breetveld
Feb 1, 1993·The British Journal of Ophthalmology·D B ArcherG Kelly
Apr 10, 2015·Ophthalmic Surgery, Lasers & Imaging Retina·Yannis M PaulusSanta J Ono
Oct 1, 1992·The British Journal of Ophthalmology·I L McAllisterI Constable
Feb 1, 1990·The British Journal of Ophthalmology·C M Wood, J Richardson
Jan 1, 1988·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·S Wakui
Apr 18, 2009·Seminars in Ophthalmology·Sandra R MontezumaJoan W Miller
Jun 11, 1992·Acta Ophthalmologica·H J FiskaadalO Naess
Feb 28, 1983·Documenta Ophthalmologica. Advances in Ophthalmology·J A Oosterhuis
Jul 1, 1990·The British Journal of Ophthalmology·P D FoxG R Serjeant

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Z R ZhuS J Ryan
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
U Schmidt-ErfurthR Birngruber
© 2021 Meta ULC. All rights reserved