PMID: 8940997Dec 1, 1996Paper

Morphologic, histologic, and molecular similarities between adenocarcinomas arising in the gastric stump and the intact stomach

Cancer
A V Safatle-RibeiroS D Finkelstein

Abstract

Patients with gastric remnants resulting from partial resections have an increased risk for carcinoma. It is unclear whether adenocarcinoma arising in the gastric stump (GSca) differs from intact stomach carcinoma (Gca). The goal of this study was to examine the pathologic and molecular features of GSca and compare them with Gca. Adjacent nonmalignant areas and tumors from 14 patients who were 19-55 years postgastrectomy (mean, 32.1 years) were compared with 14 Gca by pathologic and molecular analysis. Formalin fixed, paraffin embedded specimens were immunohistochemically stained for p53 followed by topographic genotyping. Exons 5-8 were amplified by the polymerase chain reaction and directly sequenced. No differences were noted between the two groups regarding gender, types of metaplasia, dysplasia, morphology, or histologic tumor type. However, a higher incidence of cystic dilatation and foveolar hyperplasia were present in GSca. p53 gene point mutations occurred in 5 of 14 (35.7%) GSca patients. GSca p53 mutations included missense point mutations (G:A transitions in four patients and G:C transversion in one patient) with allelic loss. In four of the five patients with p53 mutations, the same mutation was also observed in th...Continue Reading

Citations

Nov 24, 1999·Biochemical and Biophysical Research Communications·K Wakiya, M Shibuya
Sep 28, 2000·Biochemical and Biophysical Research Communications·T AsoS Kitajima
Sep 18, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shinsaku HondaMasanori Terashima
Jan 9, 2007·European Journal of Gastroenterology & Hepatology·Adriana V Safatle-RibeiroJoaquim Gama-Rodrigues

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