Morphologic Predictors and Temporal Characteristics of Conversion from Nonexudative to Exudative Age-Related Macular Degeneration in the Fellow Eye.

Ophthalmology Retina
Kelvin Yi Chong TeoChui Ming Gemmy Cheung

Abstract

To describe the systemic and ocular features of fellow eyes' association with nonexudative neovascularization (NV) based on OCT angiography (OCTA) and to identify longitudinal morphologic changes associated with progression to exudation. Cohort study of contralateral eye in patients with neovascular age-related macular degeneration (nAMD) in 1 eye. Patients with nAMD in one eye were eligble for inclusion and enrolled between June 2015 and Jan 2017. The study eye was the contralateral eye that was free of nAMD with a minimum follow-up of 1 year. Progressive multimodal imaging was performed on both eyes. Nonexudative NV was detected on OCTA in the study eye and quantitative changes analyzed. Nonexudative NV eyes were divided into progression to exudation or not during a minimum of 12 months follow-up. Association between systemic and ocular characteristics with nonexudative NV were determined. Change in OCTA size, vessel density, and vessel length density were compared between visits as predictors of progression to exudation. Among 229 study eyes, 21 (9.1%) had nonexudative NV detected on OCTA at baseline. Hyperlipidemia (adjusted odds ratio [AOR], 1.3; 95% confidence interval [CI], 1.10-3.20; P = 0.04), triglycerides (AOR, 2.84 ...Continue Reading

References

Jun 1, 1992·Ophthalmology·R KleinK L Linton
Dec 1, 1973·The British Journal of Ophthalmology·S H Sarks
May 7, 2002·American Journal of Ophthalmology·Masanobu UyamaMiyo Matsumura
Mar 12, 2004·American Journal of Ophthalmology·Hans E Grossniklaus, W Richard Green
Mar 8, 2005·Clinical and Experimental Medicine·M NowakK Nowak
Mar 12, 2005·Science·Robert J KleinJosephine Hoh
Oct 21, 2006·Science·Andrew DewanJosephine Hoh
Apr 26, 2007·JAMA : the Journal of the American Medical Association·Johanna M SeddonMichael L Klein
Jan 1, 2010·Investigative Ophthalmology & Visual Science·Nicolas LevezielEric H Souied
Mar 28, 2012·Retina·Lawrence A YannuzziNatalie Borodoker
May 9, 2012·Lancet·Laurence S LimTien Y Wong
May 29, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chui Ming Gemmy CheungTien Yin Wong
Feb 27, 2013·Investigative Ophthalmology & Visual Science·Yingfeng ZhengTien Y Wong
Oct 3, 2013·Investigative Ophthalmology & Visual Science·Giuseppe QuerquesEric H Souied
Jun 24, 2014·Ophthalmology·Javier Zarranz-VenturaUNKNOWN United Kingdom Age-Related Macular Degeneration Electronic Medical Records Users Group
Jun 28, 2014·Investigative Ophthalmology & Visual Science·Nichole JoachimJie Jin Wang
Sep 3, 2015·International Journal of Retina and Vitreous·Elona Dhrami-GavaziK Bailey Freund
Feb 13, 2017·Survey of Ophthalmology·Andrew S H TsaiChui Ming Gemmy Cheung
Jul 12, 2018·Eye·Chui Ming Gemmy CheungK Bailey Freund
Oct 4, 2018·Translational Vision Science & Technology·Alison D TreisterAmani A Fawzi

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Citations

May 14, 2021·Investigative Ophthalmology & Visual Science·Mengxi ShenPhilip J Rosenfeld
Jun 1, 2021·American Journal of Ophthalmology·Alessandro InvernizziKelvin Yi Chong Teo

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