Abstract
Vein bypass grafts in 8 patients were examined by light microscopy (LM) only or, in addition, by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) before stretching, after stretching and immediately before implantation. Before stretching, the endothelium showed only discrete changes and detachment of the endothelium was rare. After stretching severe endothelial damage was evident, including loss of large areas of endothelium and extensive endothelial tears. Before implantation there had been an extension of the tears and the endothelial detachment in individual preparations. The most important factor causing damage is stretching of the vein. The incubation medium may also play a significant role. Damage incurred before operation or during removal, and hypoxia are of lesser importance. By avoiding endothelial damage it should be possible to limit the occurrence of early postoperative thrombosis and possibly severe late changes as well.
Citations
Apr 1, 1995·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·G J CooperG D Angelini
Dec 15, 2005·Heart, Lung & Circulation·Shahzad G RajaHaider Zaman
Jul 1, 1989·Lancet·M PfistererP Stulz
Jul 17, 2010·Pathology·Sayyed Mohammad Hossein GhaderianReza Akbarzadeh Najar
Dec 15, 2005·Heart, Lung & Circulation·Shahzad Gull RajaHaider Zaman
Feb 6, 1998·The Journal of Thoracic and Cardiovascular Surgery·J D MannionA Zalewski
Sep 20, 2005·Journal of Structural Biology·Tobias ReichlinMartin Stolz
Dec 19, 2001·Journal of Cardiothoracic and Vascular Anesthesia·W W WendlingC Carlsson
Jan 1, 1984·Biomaterials, Medical Devices, and Artificial Organs·H Ben-SimhonR Guidoin
Jun 1, 1996·The Journal of Pathology·L D ButteryJ M Polak
Jun 17, 1997·Circulation·Y ShiA Zalewski
Sep 13, 2012·Cardiology in Review·Francis Y KimDavid J Whellan
Mar 1, 1981·Gut·S N Joffe