Morphological adaptations of human liver peroxisomes in cholestasis

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
D de CraemerC Van den Branden

Abstract

Part of the bile acid synthesis takes place in peroxisomes. An altered enterohepatic circulation of bile acids might influence peroxisomal beta-oxidation enzymes and peroxisomal morphology. We performed a morphological and morphometric investigation of peroxisomes in liver biopsy samples of eight patients with cholestasis of different origin: graft versus host reaction (n = 1), obstruction of the bile flow (n = 3), and drug-induced cholestatic hepatitis (n = 4). Peroxisomes were identified using catalase cytochemistry. They were regularly shaped and showed individual differences in electron density. A perinuclear distribution was observed in a variable number of hepatocytes in each sample. Morphometric analysis of peroxisomes revealed an increase in numerical density and surface density in all, and a decreased mean diameter in four liver samples. Based on previously obtained data in experimental animals, we hypothesize that the observed alterations in peroxisomal morphology indicate an enhanced metabolic activity of the enzymes in the peroxisomal matrix. Among them are enzymes involved in bile acid synthesis.

References

May 26, 1992·Biochemistry·D W Russell, K D Setchell
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Z R VlahcevicP B Hylemon
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D De CraemerF Roels
Jan 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F RoelsS Goldfischer
Jan 1, 1995·Journal of Inherited Metabolic Disease·I KerckaertG Van Limbergen
Jan 1, 1995·Journal of Inherited Metabolic Disease·D De Craemer
Jan 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Frank RoelsSidney Goldfischer

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Citations

Apr 12, 2006·Physical Review Letters·Nan-Yow ChenChung-Yu Mou
Feb 20, 2020·Combinatorial Chemistry & High Throughput Screening·Shreya BhattacharyaSujay Ray

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