PMID: 9189302Jun 1, 1997Paper

Morphological adaptations of neuromuscular junctions depend on fiber type

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée
Gary C Sieck, Y S Prakash

Abstract

The neuromuscular junction (NMJ) forms the communicative link between motoneurons and muscle fibers. The properties of motoneurons and muscle fibers are matched in different types of motor units, which are recruited selectively to accomplish various motor behaviors. Motor units and muscle fibers can be classified based upon structural and functional properties, reflecting the essential match between motoneuron and muscle fiber. Using a three-color immunofluorescence technique combined with confocal microscopy, we examined the three-dimensional structure of pre- and postsynaptic elements of NMJs on different fiber types in the rat diaphragm muscle. On type I and IIa fibers, comprising slow-twitch and fast-twitch fatigue-resistant motor units, the structure of NMJs is far less complex than on type IIx6 and IIb fibers comprising fast-twitch fatigue-intermediate and fast-twitch fatigable motor units. We also found a greater extent of overlap between pre- and postsynaptic elements of NMJs on type I and IIa fibers. This review focuses on these normal phenotypic differences in NMJ properties and on the adaptations that occur under various conditions of altered use.

Citations

Oct 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Brenda Toscano-MárquezGabriel Gutiérrez-Ospina
May 3, 2014·American Journal of Respiratory and Critical Care Medicine·François MaltaisUNKNOWN ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD
Aug 13, 2014·The Journal of Surgical Research·Lina HuangShitong Li
Nov 9, 2011·Respiratory Physiology & Neurobiology·Dylan C SieckCarlos B Mantilla
Sep 12, 2009·Respiratory Physiology & Neurobiology·Carlos B Mantilla, Gary C Sieck
Nov 1, 2015·Experimental Gerontology·Sarah M GreisingCarlos B Mantilla
Sep 29, 2015·Journal of Neurotrauma·Santiago Alvarez-ArgoteCarlos B Mantilla
Dec 25, 2003·Muscle & Nerve·Anteneh ArgawPhillip F Gardiner
Oct 13, 2004·Muscle & Nerve·Carlos B MantillaGary C Sieck
Feb 9, 2007·Muscle & Nerve·Leonid G ErmilovGary C Sieck
May 3, 2019·Journal of Neurophysiology·Matthew J FogartyGary C Sieck
Feb 15, 2007·Muscle & Nerve·Lynne R Sheffler, John Chae
Feb 7, 2003·Journal of Applied Physiology·Carlos B Mantilla, Gary C Sieck
Oct 29, 2000·Journal of Applied Physiology·D A Homonko, E Theriault
Aug 30, 2014·Journal of Applied Physiology·Carlos B MantillaGary C Sieck
Feb 22, 2001·Journal of Applied Physiology·P DesaulniersP F Gardiner
Jul 26, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Poulomee BosePierre Drapeau
Apr 9, 2021·Journal of Applied Physiology·Jacob R SorensenSarah M Greising
Jun 12, 2021·Scientific Reports·Alan Mejia MazaCarole H Sudre
Apr 6, 2021·Aging and Disease·Sandra Fuertes-Alvarez, Ander Izeta

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