PMID: 2124543Nov 26, 1990Paper

Morphological alterations of Xenopus oocytes induced by valine-14 p21rho depend on isoprenylation and are inhibited by Clostridium botulinum C3 ADP-ribosyltransferase

FEBS Letters
C MohrK Aktories

Abstract

Microinjection of the constitutively active recombinant Val-14 p21rho A into Xenopus oocytes induced dramatic morphological changes with redistribution of pigments from the animal pole resulting in spotted oocytes. The effects induced by Val-14 p21rho A were regulated by progesterone in a dose-dependent manner whereas prior ADP-ribosylation of the rho protein blocked its activity. About 30 min after microinjection, p21 rho was associated with the plasma membrane. The membrane association of p21rho and its biological activity were inhibited by lovastatin, an inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A reductase. The findings suggest that membrane attachment and biological activity of p21rho depend on isoprenylation of the GTP-binding protein.

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Citations

Jan 1, 1993·Cellular Signalling·S Narumiya, N Morii
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M C GongA P Somlyo
Sep 1, 1995·The Journal of Cell Biology·G SchmalzingK Aktories
Aug 7, 2004·Journal of Pharmacological Sciences·Yoshihiko ChibaMiwa Misawa
Aug 9, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Keiji ItohSergei Y Sokol
Jan 12, 2002·The Journal of Biological Chemistry·Maria DiakonovaChristin Carter-Su
Apr 18, 1997·The Journal of Biological Chemistry·M C GongA P Somlyo

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