PMID: 9532943Apr 9, 1998Paper

Morphological alternations and hemostatic disturbances as manifestation of mesenchymal dysplasia in nephroptosis patients

Urologii︠a︡ i nefrologii︠a︡
A I NeĭmarkT S Taranina

Abstract

The examination of 36 nephroptosis patients (33 females and 3 males, mean age 23 years) included assessment of hemostasis before and after nephropexia (15 patients), histological investigation of renal parenchyma biopsies (15 patients) and those of the skin from the lateral abdominal surface and musculus lumborum fascia (5 patients). Changes characteristic for an early stage of microcystosis were found in all the renal tissue biopsies. In the skin and muscular connective tissue there were dystrophic changes. Collagen fibers were undergoing elastoid degeneration. As to hemostatic disorders, there were diverse platelet dysfunctions and/or thrombocytopenias, 9 patients had low plasma level of Willebrand's factor, 28 showed impaired terminal clotting. Combination of the above defects was registered in 12 of 36 examinees. After nephropexia, platelet count and fibrinogen level noticeably increased, hemostatic disorders aggravated. Thus, nephroptosis is manifestation of connective tissue pathology associated with marked hemostatic changes.

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Arkhiv patologii
I V DvorakovskaiaD N Cherniakova
Vestnik Rossiĭskoĭ akademii meditsinskikh nauk
O G IurinV V Pokrovskiĭ
© 2022 Meta ULC. All rights reserved